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Part of the Immune System That Is Affected
Disorder
Humoral immunity: Problems with B cells (lymphocytes) and their production of antibodies
Common variable immunodeficiency Common Variable Immunodeficiency (CVID) Common variable immunodeficiency is an immunodeficiency disorder characterized by very low antibody (immunoglobulin) levels despite a normal number of B cells (lymphocytes). People with common... read more
Deficiency of a specific antibody (selective immunoglobulin deficiency Selective Immunoglobulin Deficiency Selective immunoglobulin deficiency is usually inherited. It results in a low level of one type (class) of antibody (immunoglobulin), even though the levels of other immunoglobulins are normal... read more ), such as IgA deficiency
Transient hypogammaglobulinemia of infancy Transient Hypogammaglobulinemia of Infancy In transient hypogammaglobulinemia of infancy, production of normal amounts of antibodies (immunoglobulins) in infants is delayed. (See also Overview of Immunodeficiency Disorders.) At birth... read more
X-linked agammaglobulinemia X-Linked Agammaglobulinemia X-linked agammaglobulinemia is a hereditary immunodeficiency disorder due to a mutation in a gene on the X (sex) chromosome. The disorder results in no B cells (a type of lymphocyte) and very... read more
Cellular immunity: Problems with T cells (lymphocytes)
Chronic mucocutaneous candidiasis Chronic Mucocutaneous Candidiasis Chronic mucocutaneous candidiasis, a hereditary immunodeficiency disorder, is persistent or recurring infection with Candida (a fungus) due to malfunction of T cells (lymphocytes). Chronic mucocutaneous... read more
DiGeorge syndrome DiGeorge Syndrome DiGeorge syndrome is a congenital immunodeficiency disorder in which the thymus gland is absent or underdeveloped at birth. Children with DiGeorge syndrome are born with several abnormalities... read more
X-linked lymphoproliferative syndrome X-Linked Lymphoproliferative Syndrome X-linked lymphoproliferative syndrome results from an abnormality in T cells and natural killer cells and results in an abnormal response to Epstein-Barr virus infection. People with X-linked... read more
Combined humoral and cellular immunity: Problems with B and T cells
Ataxia-telangiectasia Ataxia-Telangiectasia Ataxia-telangiectasia is a hereditary disorder characterized by incoordination, dilated capillaries, and an immunodeficiency that causes increased susceptibility to infections. In children with... read more
Hyperimmunoglobulinemia E syndrome Hyper-IgE Syndrome Hyper-IgE syndrome is a hereditary immunodeficiency disorder characterized by recurring boils, sinus and lung infections, and a severe rash that appear during infancy. Levels of immunoglobulin... read more
Severe combined immunodeficiency Severe Combined Immunodeficiency (SCID) Severe combined immunodeficiency is a primary immunodeficiency disorder resulting in low levels of antibodies (immunoglobulins) and low or no T cells (lymphocytes). Most infants with severe... read more
Wiskott-Aldrich syndrome Wiskott-Aldrich Syndrome Wiskott-Aldrich syndrome is a hereditary immunodeficiency disorder characterized by abnormal antibody (immunoglobulin) production, T-cell (lymphocyte) malfunction, a low platelet count, and... read more
Phagocytes: Problems with the movement or killing activity of these cells
Chédiak-Higashi syndrome Chédiak-Higashi Syndrome Chédiak-Higashi syndrome is a very rare hereditary disorder characterized by recurrent bacterial respiratory and other infections and lack of pigment in the hair, eyes, and skin (albinism).... read more (rare)
Chronic granulomatous disease Chronic Granulomatous Disease (CGD) Chronic granulomatous disease is a hereditary immunodeficiency disorder in which phagocytes (a type of white blood cell) malfunction. People with chronic granulomatous disease have persistent... read more
Cyclic neutropenia Neutropenia is an abnormally low number of neutrophils (a type of white blood cell) in the blood. Neutropenia, if severe, significantly increases the risk of life-threatening infection. Neutropenia... read more
Leukocyte adhesion defects Leukocyte Adhesion Deficiency In leukocyte adhesion deficiency, white blood cells (leukocytes) do not function normally, causing frequent soft-tissue infections. Symptoms of leukocyte adhesion deficiency usually begin during... read more
Complement proteins: Deficiency of complement proteins
Complement component 1 (C1) inhibitor deficiency (hereditary angioedema Hereditary and Acquired Angioedema Hereditary angioedema (a genetic disorder) and acquired angioedema (acquired C1 inhibitor deficiency) are caused by a deficiency or malfunction of C1 inhibitor, which is part of the immune system... read more )
C3 deficiency
C4 deficiency
C5, C6, C7, C8, and/or C9 deficiency
