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Some Primary Immunodeficiency Disorders

Some Primary Immunodeficiency Disorders

Part of the Immune System That Is Affected

Disorder

Humoral immunity: Problems with B cells (lymphocytes) and their production of antibodies

Common variable immunodeficiency

Deficiency of a specific antibody (selective immunoglobulin deficiency), such as IgA deficiency

Transient hypogammaglobulinemia of infancy

X-linked agammaglobulinemia

Cellular immunity: Problems with T cells (lymphocytes)

Chronic mucocutaneous candidiasis

DiGeorge syndrome

X-linked lymphoproliferative syndrome

Combined humoral and cellular immunity: Problems with B and T cells

Ataxia-telangiectasia

Hyperimmunoglobulinemia E syndrome

Severe combined immunodeficiency

Wiskott-Aldrich syndrome

Phagocytes: Problems with the movement or killing activity of these cells

Chronic granulomatous disease

Chédiak-Higashi syndrome (rare)

Cyclic neutropenia

Leukocyte adhesion defects

Complement proteins: Deficiency of complement proteins

Complement component 1 (C1) inhibitor deficiency (hereditary angioedema)

C3 deficiency

C4 deficiency

C5, C6, C7, C8, and/or C9 deficiency

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