Merck Manual

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Drugs That Can Damage the Liver

Drugs That Can Damage the Liver

Type of Drug

Examples

Antibiotics

Amoxicillin/clavulanate

Clindamycin

Erythromycin

Nitrofurantoin

Rifampin

Sulfonamides

Tetracyclines

Trimethoprim/sulfamethoxazole

Drugs used to treat tuberculosis (isoniazid and pyrazinamide)

Anticonvulsants

Carbamazepine

Phenobarbital

Phenytoin

Valproate

Antidepressants

Bupropion

Fluoxetine

Mirtazapine

Paroxetine

Sertraline

Trazodone

Tricyclic antidepressants such as amitriptyline

Antifungal drugs

Ketoconazole

Terbinafine

Antihypertensive drugs (used to treat high blood pressure or sometimes kidney or heart disorders)

Captopril

Enalapril

Irbesartan

Lisinopril

Losartan

Verapamil

Antipsychotic drugs

Phenothiazines such as chlorpromazine

Risperidone

Heart drugs

Amiodarone

Clopidogrel

Hormones and related drugs

Anabolic steroids

Birth control pills (oral contraceptives)

Estrogens

Pain relievers

Acetaminophen

NSAIDs

Other drugs

Acarbose (used to treat diabetes)

Allopurinol (used to treat gout)

ART drugs (used to treat HIV infection)

Baclofen (a muscle relaxant)

Cyproheptadine (an antihistamine)

Azathioprine (used to prevent rejection of an organ transplant)

Methotrexate (used to treat cancer)

Omeprazole (used to treat gastroesophageal reflux)

Statins (used to treat high cholesterol levels)

Many types of chemotherapy, including immune checkpoint inhibitors

Medicinal herbs

Germander

Green tea extract

Kava

Energy drinks

ART = antiretroviral therapy; HIV = human immunodeficiency virus; NSAID = nonsteroidal anti-inflammatory drug.