Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

S-Adenosyl-L-Methionine (SAMe)

By

Laura Shane-McWhorter

, PharmD, University of Utah College of Pharmacy

Last full review/revision Jul 2020| Content last modified Jul 2020
Click here for the Professional Version

Medicinal claims

SAMe is said to be effective in treating depression, osteoarthritis, gallbladder, and liver disorders, but scientific studies so far do not clearly confirm these claims. More research is needed to verify its effectiveness for depression, but it may help people who have osteoarthritis function better. Better studies are needed to evaluate whether SAMe helps people with liver disorders.

Possible side effects

No serious side effects have been reported. People with a bipolar disorder should not use SAMe because it can cause manic episodes.

Possible drug interactions

Combining antidepressant drugs with SAMe, both of which will increase serotonin levels, may cause adverse effects such as rapid heart rate and anxiety.

More Information about SAMe

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
Click here for the Professional Version
Others also read
Test your knowledge
Radiographic Contrast Agents
Radiopaque contrast agents are used during x-rays and CT scans to distinguish one structure from another or to provide greater detail. A radiopaque contrast agent that contains which of the following substances is most appropriate to use for evaluating blood vessels?
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest

Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
TOP