(See also Definition of Dermatitis.)
Exfoliative dermatitis is a manifestation of rapid epidermal cell turnover. Its cause is unknown, but it most often occurs in the context of
Up to 25% of patients have no identifiable underlying cause. Bacterial superinfection can complicate exfoliative dermatitis.
Symptoms of exfoliative dermatitis include pruritus, malaise, and chills. Diffuse erythema initially occurs in patches but spreads and involves all or nearly all of the body. Extensive epidermal sloughing leads to abnormal thermoregulation, nutritional deficiencies because of extensive protein losses, increased metabolic rate with a hypercatabolic state, and hypovolemia due to transdermal fluid losses.
Diagnosis of exfoliative dermatitis is by history and examination. Preexisting skin disease may underlie the extensive erythema and suggest a cause.
Biopsy is often nonspecific but is indicated when mycosis fungoides is suspected. Blood tests may reveal hypoproteinemia, hypocalcemia, and iron deficiency; however, these findings are not diagnostic.
Any known cause is treated. Supportive care consists of correction of dehydration, correction of electrolyte abnormalities and nutritional deficiencies, and comprehensive wound care and dressings to prevent bacterial superinfection. Because drug eruptions and contact dermatitis cannot be ruled out by history alone, all drugs should be stopped if possible or changed.
Skin care is with emollients and colloidal oatmeal baths. Weak topical corticosteroids (eg, 1 to 2.5% hydrocortisone ointment) may be used.
Corticosteroids (eg, prednisone 40 to 60 mg orally once a day for 10 days, then tapered) are used for severe disease.
Exfoliative dermatitis often occurs with preexisting skin disorders, drugs, and cancer, but the cause may be unknown.
Symptoms include pruritus, widespread erythema, and epidermal sloughing.
Diagnosis is clinical.
Hospitalization is often necessary, because the disease may be life threatening.
Treatment consists of supportive care, comprehensive wound and skin care, and systemic corticosteroids for severe disease.