Respiratory Alkalosis

ByJames L. Lewis III, MD, Brookwood Baptist Health and Saint Vincent’s Ascension Health, Birmingham
Reviewed/Revised Jul 2023
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Respiratory alkalosis is a primary decrease in carbon dioxide partial pressure (P) with or without compensatory decrease in bicarbonate (HCO); pH may be high or near normal. Cause is an increase in respiratory rate or volume (hyperventilation) or both. Respiratory alkalosis can be acute or chronic. The chronic form is asymptomatic, but the acute form causes light-headedness, syncope, confusion, paresthesias, and cramps. Signs include hyperpnea or tachypnea and carpopedal spasms. Diagnosis is clinical and with arterial blood gas (ABG) and serum electrolyte measurements. Treatment is directed at the cause.

(See also Acid-Base Regulation, Acid-Base Disorders, and Hyperventilation Syndrome.)

Etiology of Respiratory Alkalosis

Respiratory alkalosis is a primary decrease in Pco2 (hypocapnia) due to an increase in respiratory rate and/or volume (hyperventilation). Ventilation increase occurs most often as a physiologic response to hypoxia (eg, at high altitude), metabolic acidosis, and increased metabolic demands (eg, fever) and, as such, is present in many serious conditions. In addition, pain and anxiety and some central nervous system (CNS) disorders (eg, stroke, seizure [post-ictal]) can increase respirations without a physiologic need.

Pathophysiology of Respiratory Alkalosis

Respiratory alkalosis can be

  • Acute

  • Chronic

The distinction is based on the degree of metabolic compensation. Excess HCO3 is buffered by extracellular hydrogen ion (H+) within minutes (acute), but more significant compensation occurs over 2 to 3 days (chronic) as the kidneys decrease H+ excretion.

Pseudorespiratory alkalosis

Pseudorespiratory alkalosis is low arterial Pco2 and high pH in patients being treated with mechanical ventilation who have severe metabolic acidosis due to poor systemic perfusion (eg, cardiogenic shock, during CPR [cardiopulmonary resuscitation]). Pseudorespiratory alkalosis occurs when mechanical ventilation (often hyperventilation) eliminates larger-than-normal amounts of alveolar carbon dioxide (CO2). Exhalation of large amounts of CO2 causes respiratory alkalosis in arterial blood (hence on ABG measurements), but poor systemic perfusion and cellular ischemia cause cellular acidosis, leading to acidosis of venous blood.

Diagnosis is by demonstration of marked differences in arterial and venous Pco2 and pH and by elevated lactate levels in patients whose ABG measurement shows respiratory alkalosis.

Treatment is improvement of systemic hemodynamics.

Symptoms and Signs of Respiratory Alkalosis

Symptoms and signs depend on the rate and degree of fall in Pco2. Acute respiratory alkalosis causes light-headedness, confusion, peripheral and circumoral paresthesias, cramps, and syncope. Mechanism is thought to be change in cerebral blood flow and pH. Tachypnea or hyperpnea is often the only sign; carpopedal spasm may occur in severe cases due to decreased levels of ionized calcium in the blood (driven inside cells in exchange for hydrogen ion [H+]).

Chronic respiratory alkalosis is usually asymptomatic and has no distinctive signs.

Diagnosis of Respiratory Alkalosis

  • Arterial blood gas (ABG) and serum electrolyte measurements

  • If hypoxia present, cause vigorously pursued

Recognition of respiratory alkalosis and appropriate renal compensation (see Diagnosis of Acid-Base Disorders) requires ABG and serum electrolyte measurements. Minor hypophosphatemia and hypokalemia due to intracellular shifts and decreased ionized calcium (Ca++) due to an increase in protein binding may be present.

Presence of hypoxia or an increased alveolar-arterial (A-a) O2 gradient (inspired Po2 [arterial Po2+ 5/4 arterial Pco2]) requires search for a cause.

Causes are often apparent based on history and examination findings. However, because pulmonary embolism often manifests without hypoxia, embolism must be strongly considered in a patient who is hyperventilating before ascribing the cause to anxiety alone.

Clinical Calculators

Treatment of Respiratory Alkalosis

  • Treatment of underlying disorder

Treatment is directed at finding and treating the underlying disorder. Respiratory alkalosis itself is not life threatening, so no interventions to lower pH are necessary. Increasing inspired carbon dioxide through rebreathing (such as from a paper bag) is common practice but may be dangerous in at least some patients with CNS disorders in whom the pH of cerebrospinal fluid may already be below normal.

Key Points

  • Respiratory alkalosis involves an increase in respiratory rate and/or tidal volume (hyperventilation).

  • Hyperventilation occurs most often as a response to hypoxia, metabolic acidosis, increased metabolic demands (eg, fever), pain, or anxiety.

  • Do not presume anxiety is the cause of hyperventilation until more serious disorders are excluded.

  • Treat the cause; respiratory alkalosis is not life threatening, so interventions to lower pH are unnecessary.

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