Mupirocin inhibits bacterial RNA and protein synthesis. It is available only as a 2% topical preparation, which is bactericidal against staphylococci and beta-hemolytic streptococci. Systemic absorption of topical mupirocin is negligible.
Mupirocin is used for
Chronic therapy leads to mupirocin-resistant staphylococci.
Mupirocin is nontoxic but, when applied to denuded skin or mucous membranes, may cause itching and burning.