Merck Manual

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Brian J. Werth

, PharmD,

  • Assistant Professor of Pharmacy
  • University of Washington School of Pharmacy

Last full review/revision May 2020| Content last modified May 2020
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Spectinomycin is a bacteriostatic antibiotic chemically related to the aminoglycosides. Spectinomycin binds to the 30S subunit of the ribosome, thus inhibiting bacterial protein synthesis. Its activity is restricted to gonococci. Spectinomycin is excreted by glomerular filtration.

Indications include

Spectinomycin is not effective for gonococcal pharyngitis. It is not available in the US, and where available, it is reserved for patients who cannot be treated with ceftriaxone or cefixime plus azithromycin or doxycycline.

Adverse effects, including hypersensitivity reactions and fever, are rare.

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