Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected Symptoms and Signs Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei... read more . The anatomy of the spinal column Anatomy Spinal cord disorders can cause permanent severe neurologic disability. For some patients, such disability can be avoided or minimized if evaluation and treatment are rapid. The spinal cord... read more is reviewed elsewhere.
Spinal cord injury may be
(See also Approach to the Trauma Patient Approach to the Trauma Patient Injury is the number one cause of death for people aged 1 to 44. In the US, there were 278,345 trauma deaths in 2020, about 70% of which were accidental. Of intentional injury deaths, more than... read more .)
Spinal cord injury
During a typical year, there are about 12,000 spinal cord injuries in the US or 40 cases per million persons per year.
The most common causes of spinal cord injuries are
Motor vehicle crashes (48%)
The remainder of spinal cord injuries are attributed to assault (12%), sports (10%), and work-related injuries. About 80% of patients are male.
In older patients, falls are the most common cause. Osteoporotic bones and degenerative joint disease may increase the risk of cord injury at lower impact velocities due to angulations formed by the degenerated joints, osteophytes impinging on the cord, and brittle bone allowing for easy fracture through critical structures.
Spinal cord injuries occur when blunt physical force damages the vertebrae, ligaments, or disks of the spinal column, causing bruising, crushing, or tearing of spinal cord tissue, and when the spinal cord is penetrated (eg, by a gunshot or a knife wound). Such injuries can also cause vascular injury with resultant ischemia or hematoma (typically extradural), leading to further damage. All forms of injury can cause spinal cord edema, further decreasing blood flow and oxygenation. Damage may be mediated by excessive release of neurotransmitters from damaged cells, an inflammatory immune response with release of cytokines, accumulation of free radicals, and apoptosis.
Vertebral injuries may be
Fractures, which may involve the vertebral body, lamina, and pedicles as well as the spinous, articular, and transverse processes
Dislocations, which typically involve the facets
Subluxations, which may involve ligament rupture without bony injury
In the neck, fractures of the posterior elements and dislocations can damage the vertebral arteries, causing a syndrome resembling a brain stem stroke.
Unstable vertebral injuries are those in which bony and ligamentous integrity are disrupted sufficiently that free movement can occur, potentially compressing the spinal cord or its vascular supply and resulting in marked pain and potential worsening of neurologic function. Such vertebral movement may occur even with a shift in patient position (eg, for ambulance transport, during initial evaluation). Stable vertebral fractures are able to resist such movement.
Specific injuries typically vary with mechanism of trauma. Flexion injuries can cause wedge fractures of the vertebral body or spinous process fractures. Greater flexion force may cause bilateral facet dislocation, or if the force occurs at the level of C1 or C2, odontoid fracture, atlanto-occipital or atlantoaxial subluxation Atlantoaxial Subluxation Atlantoaxial subluxation is misalignment of the 1st and 2nd cervical vertebrae, which may occur only with neck flexion. (See also Evaluation of Neck and Back Pain and Craniocervical Junction... read more , or both fracture and subluxation. Rotational injury can cause unilateral facet dislocation. Extension injury most often causes posterior neural arch fracture. Compression injuries can cause burst fractures of vertebral bodies.
Cauda equina injury
The lower tip of the spinal cord (conus medullaris) is usually at the level of the L1 vertebra. Spinal nerves below this level comprise the cauda equina. Thus, findings in spinal injuries below this level may mimic those of spinal cord injury, particularly conus medullaris syndrome (see Table Spinal Cord Syndromes Spinal Cord Syndromes ).
Symptoms and Signs
The cardinal sign of spinal cord injury is a discrete injury level in which neurologic function above the injury is intact, and function below the injury is absent or markedly diminished. Muscle strength is assessed How to Assess Muscle Strength Patients who report weakness may mean fatigue, clumsiness, or true muscle weakness. Thus, the examiner must define the precise character of symptoms, including exact location, time of occurrence... read more using the standard 0 to 5 scale. Specific manifestations depend on the exact level (see table Effects of Spinal Cord Injury by Location Effects of Spinal Cord Injury by Location ) and whether cord injury is complete or incomplete. Priapism Priapism Priapism is painful, persistent, abnormal erection unaccompanied by sexual desire or excitation. It is most common in boys aged 5 to 10 years and in men aged 20 to 50 years. The penis is composed... read more may occur in the acute phase of spinal cord injury.
In addition to motor and sensory function, upper motor neuron signs are an important finding in cord injury. These signs include increased deep tendon reflexes and muscle tone, a plantar extensor response (upgoing toe), clonus (most commonly found at the ankle by rapidly flexing the foot upward), and a Hoffman reflex (a positive response is flexion of the terminal phalanx of the thumb after flicking the nail of the middle finger).
Vertebral injury, as with other fractures and dislocations, typically is painful, but patients who are distracted by other painful injuries (eg, long bone fractures) or whose level of consciousness is altered by intoxicants or head injury may not complain of pain.
Complete cord injury
Complete spinal cord injury leads to
Immediate, complete, flaccid paralysis (including loss of anal sphincter tone)
Loss of all sensation and reflex activity
Autonomic dysfunction below the level of the injury
High cervical injury (at or above C5) affects the muscles controlling respiration, causing respiratory insufficiency; ventilator dependence may occur, especially in patients with injuries at or above C3. Autonomic dysfunction due to cervical cord injury can result in bradycardia and hypotension; this condition is termed neurogenic shock. Unlike in other forms of shock, the skin remains warm and dry. Arrhythmias Overview of Arrhythmias The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial... read more and blood pressure instability may develop. Pneumonia Overview of Pneumonia Pneumonia is acute inflammation of the lungs caused by infection. Initial diagnosis is usually based on chest x-ray and clinical findings. Causes, symptoms, treatment, preventive measures, and... read more is a frequent cause of death in people with a high cervical cord injury, especially in those who are ventilator dependent.
Flaccid paralysis gradually changes over hours or days to spastic paralysis with increased deep tendon reflexes due to loss of descending inhibition. Later, if the lumbosacral cord is intact, flexor muscle spasms appear and autonomic reflexes return.
Incomplete cord injury
In incomplete spinal cord injury, motor and sensory loss occurs, and deep tendon reflexes may be hyperactive. Motor and sensory loss may be permanent or temporary, depending on the etiology; function may be lost briefly due to concussion or more lastingly due to a contusion or laceration. Sometimes, however, rapid swelling of the cord results in total neurologic dysfunction that resemble complete cord injury; this condition is termed spinal shock (not to be confused with neurogenic shock). Symptoms resolve over one to several days, but residual disability often remains.
Brown-Séquard syndrome results from unilateral hemisection of the cord. Patients have ipsilateral spastic paralysis and loss of position sense below the lesion, and contralateral loss of pain and temperature sensation.
Anterior cord syndrome results from direct injury to the anterior spinal cord or to the anterior spinal artery. Patients lose motor and pain sensation bilaterally below the lesion. Posterior cord function (vibration, proprioception) is intact.
Central cord syndrome usually occurs in patients with a narrowed cervical spinal canal (congenital or degenerative) after a hyperextension injury. Motor function in the arms is impaired to a greater extent than that in the legs. If the posterior columns are affected, posture, vibration, and light touch are lost. If the spinothalamic tracts are affected, pain, temperature, and, often, light or deep touch are lost. Hemorrhage in the spinal cord resulting from trauma (hematomyelia) is usually confined to the cervical central gray matter, resulting in signs of lower motor neuron damage (muscle weakness and wasting, fasciculations, and diminished tendon reflexes in the arms), which is usually permanent. Motor weakness is often proximal and accompanied by selective impairment of pain and temperature sensation.
Cauda equina lesions
Motor loss or sensory loss, or both, usually partial, occurs in the distal legs. Sensory symptoms are generally bilateral but usually asymmetric, affecting one side more than the other. Sensation is usually diminished in the perineal region (saddle anesthesia). Bowel and bladder dysfunction, either incontinence or retention, may occur. Men may have erectile dysfunction Erectile Dysfunction Erectile dysfunction is the inability to attain or sustain an erection satisfactory for sexual intercourse. Most erectile dysfunction is related to vascular, neurologic, psychologic, and hormonal... read more , and women diminished sexual response. Anal sphincter tone is lax, and bulbocavernosus and anal wink reflexes are abnormal. These findings may be similar to those of conus medullaris syndrome.
Complications of spinal cord injury
Sequelae depend on the severity and level of the injury. Breathing may be impaired if the injury is at or above the C5 segment. Reduced mobility increases the risk of blood clots, urinary tract infections Introduction to Urinary Tract Infections (UTIs) Urinary tract infections (UTIs) can be divided into upper tract infections, which involve the kidneys ( pyelonephritis), and lower tract infections, which involve the bladder ( cystitis), urethra... read more , contractures, atelectasis Atelectasis Atelectasis is collapse of lung tissue with loss of volume. Patients may have dyspnea or respiratory failure if atelectasis is extensive. They may also develop pneumonia. Atelectasis is usually... read more , pneumonia Overview of Pneumonia Pneumonia is acute inflammation of the lungs caused by infection. Initial diagnosis is usually based on chest x-ray and clinical findings. Causes, symptoms, treatment, preventive measures, and... read more , and pressure ulcers Pressure Injuries Pressure injuries are areas of necrosis and often ulceration (also called pressure ulcers) where soft tissues are compressed between bony prominences and external hard surfaces. They are caused... read more . Disabling spasticity may develop. Cardiovascular instability is common soon after cervical cord injury and is related to neurogenic shock and autonomic dysreflexia that occur in response to triggering events such as pain or pressure on the body. Chronic neurogenic pain may manifest as burning or stinging.
Consideration of injury in high-risk patients, even those without symptoms
Spinal injuries resulting from trauma are not always obvious. Injury to the spine and spinal cord must be considered in patients with
Injuries that involve the head
Penetrating injuries in the area of the spine
Injuries sustained in motor vehicle crashes
Severe blunt injuries
Injuries sustained by falling from heights or diving into water
In older patients, spinal column injury must also be considered after minor falls.
Injury to the spine and spinal cord should also be considered in patients with altered sensorium, localized spinal tenderness, painful distracting injuries, or compatible neurologic deficits.
Diagnosis of spine and spinal cord injuries includes assessment of nerve function, including reflex, motor, and sensation, and imaging.
Manifestations of injury may be characterized using the ASIA (American Spinal Injury Association) Impairment Scale or a similar instrument (see table Spinal Injury Impairment Scale Spinal Injury Impairment Scale* ).
Motor function is tested in all extremities. Sensation testing should involve both light touch (posterior column function), pinprick (anterior spinothalamic tract), and position sense. Identification of the sensory level is best done by testing from distal to proximal and by testing thoracic roots on the back to avoid being misled by the cervical cape. Priapism Priapism Priapism is painful, persistent, abnormal erection unaccompanied by sexual desire or excitation. It is most common in boys aged 5 to 10 years and in men aged 20 to 50 years. The penis is composed... read more indicates spinal cord damage. Rectal tone may be decreased, and deep tendon reflexes may be exuberant or absent.
Traditionally, plain x-rays are taken of any possibly injured areas. CT is done of areas that appear abnormal on x-rays and areas at risk of injury based on clinical findings. However, CT is being used increasingly as the primary imaging study for spinal trauma because it has better diagnostic accuracy and, at many trauma centers, can be obtained rapidly.
MRI helps identify the type and location of cord injury; it is the most accurate study for imaging the spinal cord and other soft tissues but may not be immediately available.
If a fracture passes through the transverse foramen of a cervical vertebrae, a vascular study is usually warranted (typically, CT angiography CT angiography CT shows a focal area of osteolysis (arrows) involving the right acetabulum that is consistent with particle disease. In CT, an x-ray source and x-ray detector housed in a doughnut-shaped assembly... read more ) to rule out a dissection of the vertebral artery.
Transection of the spinal cord results in irreparable injury and permanent loss of neurologic function below the injury site. Nerve root avulsion also causes permanent loss of function; less severe traumatic injuries from compression or stretching of the nerve tissue can result in recovery of function, depending on the degree of injury to the axons, endoneurium, and epineurium. (See Seddon's classification [ 1 Prognosis references Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected. The anatomy of the spinal column is reviewed elsewhere. Spinal... read more ] and Sunderland's classification [ 2 Prognosis references Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected. The anatomy of the spinal column is reviewed elsewhere. Spinal... read more ].) Return of some movement or sensation during the first week after injury heralds a favorable recovery. Dysfunction remaining after 6 months is likely to be permanent; however, the American Spinal Injury Association (ASIA) grade may improve by one grade for up to one year after injury. Some research demonstrates return of some function in previous complete spinal cord injuries with spinal cord stimulation.
Maintenance of oxygenation and spinal cord perfusion
Surgical stabilization when appropriate
Long-term symptomatic care and rehabilitation
Guidelines for the management of acute cervical spine and spinal cord injuries are available from the American Association of Neurological Surgeons and the Congress of Neurological Surgeons (1 Treatment references Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected. The anatomy of the spinal column is reviewed elsewhere. Spinal... read more ).
An important goal is to prevent secondary injury to the spine or spinal cord.
In unstable injuries, flexion or extension of the spine can contuse or transect the cord. Thus, when injured people are moved, inappropriate handling can precipitate paraplegia, quadriplegia, or even death due to spinal injury.
Patients who may have a spinal injury should have the spine immobilized immediately; the neck is held straight manually (inline stabilization) during endotracheal intubation Tracheal Intubation Most patients requiring an artificial airway can be managed with tracheal intubation, which can be Orotracheal (tube inserted through the mouth) Nasotracheal (tube inserted through the nose)... read more . As soon as possible, the spine is fully immobilized on a firm, flat, padded backboard or similar surface to stabilize the position without excessive pressure. A rigid collar should be used to immobilize the cervical spine. Patients with thoracic or lumbar spine injuries can be carried prone or supine. Those with cervical cord damage that could induce respiratory difficulties should be carried supine, with attention to maintaining a patent airway and avoiding chest constriction. Transfer to a trauma center is desirable.
Medical care should be directed at avoiding hypotension and hypoxia, both of which can further stress the injured cord. Many experts advocate maintaining mildly elevated blood pressure with mean arterial pressure (MAP) ≥ 85 to 90 mm Hg for 5 to 7 days to improve spinal cord perfusion and to reduce hypotensive episodes that may adversely affect recovery (1, 2, 3 Treatment references Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected. The anatomy of the spinal column is reviewed elsewhere. Spinal... read more ). MAP targets can be achieved using volume repletion with crystalloids and/or colloids, vasopressors, or a combination. Injuries above T6–T7, because they compromise sympathetic output to the thoracic cardiopulmonary nerves, are treated with vasopressors that have chronotropic and inotropic effects such as norepinephrine and dopamine. Lesions below T7 may respond sufficiently to pure vasoconstrictors such as phenylephrine. Oxygen saturation should be maintained ≥90% to prevent cord ischemia. In cervical injuries above C5, which compromise phrenic nerve input, intubation and respiratory support are usually needed.
Large doses of corticosteroids, started within 8 hours after spinal cord injury, have long been used in attempts to improve the outcome in blunt injuries, but multiple randomized clinical trials in adults have not only failed to demonstrate any added clinical benefit but have also documented increased risk of wound infection, pulmonary embolism Pulmonary Embolism (PE) Pulmonary embolism (PE) is the occlusion of pulmonary arteries by thrombi that originate elsewhere, typically in the large veins of the legs or pelvis. Risk factors for pulmonary embolism are... read more , sepsis Sepsis and Septic Shock Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection. In septic shock, there is critical reduction in tissue perfusion; acute failure... read more , and death (1 Treatment references Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected. The anatomy of the spinal column is reviewed elsewhere. Spinal... read more ). Thus corticosteroid use has been declining, and it is not routinely recommended by the American Association of Neurological Surgeons/Congress, although the issue remains somewhat controversial. Alternatively, guidelines by AO Spine suggest a 24-hour infusion of high-dose methylprednisolone (30 mg/kg bolus + 5.4 mg/kg/hour for 23 hours) for patients who present within 8 hours of their injury. This recommendation is based on a systematic review of all 3 randomized clinical trials that found a moderate benefit for patients who arrive at the hospital soon after injury without any increase in complications (4 Treatment references Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected. The anatomy of the spinal column is reviewed elsewhere. Spinal... read more ).
Injuries are treated with rest, analgesics, and muscle-relaxing drugs with or without surgery until swelling and local pain have subsided. Additional general treatment for trauma patients Evaluation and Treatment Injury is the number one cause of death for people aged 1 to 44. In the US, there were 278,345 trauma deaths in 2020, about 70% of which were accidental. Of intentional injury deaths, more than... read more is provided as necessary.
Unstable injuries are immobilized until bone and soft tissues have healed in proper alignment; surgery with fusion and internal fixation is sometimes needed. Patients with incomplete cord injuries can have significant neurologic improvement after decompression. In contrast, in complete injury, return of useful neurologic function below the level of the injury is unlikely. Thus, surgery aims to stabilize the spine to allow early mobilization.
Relief of compression caused by bone fragments, epidural hematoma, or acute malalignment may be needed. Many surgeons recommend bedside manual reduction even before MRI (or operation) for translation-rotational or distraction injury of the cervical spine causing active cord compression. However, in general, patients with clear neurologic deficits from spinal trauma should undergo MRI evaluation to define the soft tissue injury and rule out any active compressive pathology prior to any surgical intervention. Early surgery allows for earlier mobilization and rehabilitation. Recent retrospective and prospective studies suggest that the optimal timing of decompression surgery for incomplete cord injuries is within 24 hours of injury. For complete injuries, surgery is sometimes done in the first few days, but it is not clear that this timing affects outcome. The only randomized controlled trial so far to investigate the timing of surgery for spinal cord injury analyzed incomplete and complete cord injuries together. That study found better neurologic outcome at 6 months if decompression surgery was done within 24 hours of injury rather than later (4 Treatment references Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. Occasionally, the spinal nerves are affected. The anatomy of the spinal column is reviewed elsewhere. Spinal... read more ).
Other invasive treatments still under investigation include lumbar drain placement for cerebrospinal fluid (CSF) diversion for spinal cord injury and surgical duroplasty during decompression surgery. Both techniques aim to decrease increased intrathecal CSF pressure (and the resulting secondary injury) caused by spinal cord contusion and edema.
Nursing care includes preventing urinary and pulmonary infections and pressure ulcers—eg, by turning the immobile patient every 2 hours (on a Stryker frame when necessary). Deep venous thrombosis prophylaxis Prevention Deep venous thrombosis (DVT) is clotting of blood in a deep vein of an extremity (usually calf or thigh) or the pelvis. DVT is the primary cause of pulmonary embolism. DVT results from conditions... read more is required. An inferior vena cava filter could be considered in immobile patients who have contraindications to anticoagulation.
Long-term care after spinal cord injury
Drugs can effectively control spasticity in some patients. Baclofen 5 mg orally 3 times a day (maximum, 80 mg during a 24-hour period) and tizanidine 4 mg orally 3 times a day (maximum, 36 mg during a 24-hour period) are typically used for spasticity occurring after spinal cord injury. Intrathecal baclofen 50 to 100 mcg once a day may be considered in patients in whom oral drugs are ineffective.
Rehabilitation Spinal cord injury Rehabilitation aims to facilitate recovery from loss of function. (See also Overview of Rehabilitation.) Patients with arthritis can benefit from activities and exercises to increase joint range... read more is needed to help people recover as fully as possible. Rehabilitation, best provided through a team approach, combines physical therapies, skill-building activities, and counseling to meet social and emotional needs. The rehabilitation team is best directed by a physician with training and expertise in rehabilitation (physiatrist); it usually includes nurses, social workers, nutritionists, psychologists, physical and occupational therapists, recreational therapists, and vocational counselors.
Physical therapy focuses on exercises for muscle strengthening, passive stretch exercises to prevent contractures, and appropriate use of assistive devices such as braces, a walker, or a wheelchair that may be needed to improve mobility. Strategies for controlling spasticity, autonomic dysreflexia, and neurogenic pain are taught.
Occupational therapy focuses on redeveloping fine motor skills. Bladder and bowel management programs teach toileting techniques, which may require intermittent catheterization Bladder Catheterization Bladder catheterization is used to do the following: Obtain urine for examination Measure residual urine volume Relieve urinary retention or incontinence Deliver radiopaque contrast agents or... read more . A bowel regimen, involving timed stimulation with laxatives, is often needed.
Vocational rehabilitation involves assessing both fine and gross motor skills, as well as cognitive capabilities, to determine the likelihood for meaningful employment. The vocational specialist then helps identify possible work sites and determines need for assistive equipment and workplace modifications. Recreation therapists use a similar approach in identifying and facilitating participation in hobbies, athletics, and other activities.
Emotional care aims to combat the depersonalization and the almost unavoidable depression that occur after losing control of the body. Emotional care is fundamental to the success of all other components of rehabilitation and must be accompanied by efforts to educate the patient and encourage active involvement of family and friends.
Treatments to promote nerve regeneration and minimize scar tissue formation in the injured cord are under study. Such treatments include implantation of a polymer scaffold at the level of cord injury as well as injections of autologous, incubated macrophages; human-derived embryonic stem cell oligodendrocytes; neural stem cells; and trophic factors. Stem cell research is being done; many animal studies have shown promising results and there have been several phase I and II human clinical trials.
Implantation of an epidural stimulator is another treatment modality under investigation to improve voluntary movement after spinal cord injury. During epidural stimulation, electrical pulses are delivered to the surface of the spinal cord below the injury.
1. Hadley MN, Walters BC, Aarabi A, et al: Guidelines for the management of acute cervical spine and spinal cord injuries. Neurosurgery 72 (Supplement 3): 1–259, 2013. https://doi.org/10.1227/NEU.0b013e318276ee7e
2. Hawryluk G, Whetstone W, Saigal R, et al: Mean arterial blood pressure correlates with neurological recovery after human spinal cord injury: Analysis of high frequency physiologic data. J Neurotrauma 32(24):1958–1967, 2015. doi: 10.1089/neu.2014.3778
3. Vale FL, Burns J, Jackson AB, et al: Combined medical and surgical treatment after acute spinal cord injury: Results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J Neurosurg 87(2):239–246, 1997. doi: 10.3171/jns.1997.87.2.0239
4. Fehlings MG, Wilson JR, Tetreault LA, et al: A clinical practice guideline for the management of patients with acute spinal cord injury: Recommendations on the use of methylprednisolone sodium succinate. Global Spine J7(3 Suppl):203S-211S, 2017. doi: 10.1177/2192568217703085
5. Fehlings MG, Vaccaro A, Wilson JR, et al: Early versus delayed decompression for traumatic cervical spinal cord injury: Results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One 7(2):e32037, 2012. doi:10.1371/journal.pone.0032037
In addition to patients with obvious spinal trauma, suspect spinal cord injuries in patients at increased risk for spinal injury, including older patients who may have had a fall and patients with an altered sensorium, neurologic deficits suggesting cord injury, or localized spinal tenderness.
To ensure recognition of incomplete spinal cord injuries, test motor function and sensory function (including light touch, pinprick, and position sensation) and check for disproportionate weakness in the upper extremities.
Immediately immobilize the spine in patients at risk.
Arrange for immediate CT or, if available, MRI.
Arrange for surgery within 24 hours of injury if patients have incomplete cord injuries.
Treat irreversible spinal cord injury with multimodal rehabilitation and drugs that control spasticity.
Drugs Mentioned In This Article
|Drug Name||Select Trade|
|4-Way Nasal, Ah-Chew D, AK-Dilate, Anu-Med, Biorphen, Formulation R , Gilchew IR, Hemorrhoidal , Little Remedies for Noses, Lusonal, Mydfrin, Nasop, Nasop 12, Neofrin, Neo-Synephrine, Neo-Synephrine Cold + Allergy, Neo-Synephrine Extra Strength, Neo-Synephrine Mild, Ocu-Phrin, PediaCare Children's Decongestant, PediaCare Decongestant, PediaCare Infants' Decongestant, Sinex Nasal, Sudafed PE, Sudafed PE Children's Nasal Decongestant , Sudafed PE Congestion, Sudafed PE Sinus Congestion, Sudogest PE, Vazculep|
|A-Methapred, Depmedalone-40, Depmedalone-80 , Depo-Medrol, Medrol, Medrol Dosepak, Solu-Medrol|
|ED Baclofen, FLEQSUVY, Gablofen, Lioresal, Lioresal Intrathecal, LYVISPAH, OZOBAX|