Merck Manual

Please confirm that you are a health care professional

Loading

Overview of Crystal-Induced Arthritides

By

Brian F. Mandell

, MD, PhD, Cleveland Clinic

Last full review/revision Oct 2020| Content last modified Oct 2020
Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version

Arthritis can result from intra-articular deposition of crystals:

  • Monosodium urate

  • Calcium pyrophosphate dihydrate

  • Basic calcium phosphate (apatite)

  • Rarely, others such as calcium oxalate crystals

Definite diagnosis requires synovial fluid analysis. Polarized light microscopy is used to specifically identify most crystals; basic calcium phosphate crystals are of ultramicroscopic size and require other methods. Crystals may be engulfed in white blood cells or may be extracellular; either is diagnostic of crystal-induced arthritis. The presence of crystals does not exclude the possibility of simultaneous infectious or other inflammatory forms of arthritis. Noninvasive identification of monosodium urate and calcium pyrophosphate dihydrate crystals is possible using ultrasonography, but not all ultrasonographers have sufficient expertise to make this diagnosis reliably. Dual-energy CT imaging can also be used to detect uric acid deposition, but neither imaging is 100% sensitive.

Crystal-induced arthritides include the following:

Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Also of Interest

Videos

View All
How to Examine the Neck
Video
How to Examine the Neck
3D Models
View All
Flexor Tendon Sheaths of the Fingers
3D Model
Flexor Tendon Sheaths of the Fingers

SOCIAL MEDIA

TOP