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Overview of Seronegative Spondyloarthropathies

(Seronegative Spondyloarthritides)

By

Apostolos Kontzias

, MD, Stony Brook University School of Medicine

Last full review/revision May 2020| Content last modified May 2020
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Seronegative spondyloarthropathies (seronegative spondyloarthritides) share certain clinical characteristics (eg, inflammatory back pain, uveitis, gastrointestinal symptoms, rashes). Some are strongly associated with the human leukocyte antigen B27 (HLA-B27) allele. Clinical and genetic similarities suggest that they also share similar causes or pathophysiologies. Rheumatoid factor (RF) is usually negative in the spondyloarthropathies (hence, why they are called seronegative spondyloarthropathies). They include ankylosing spondylitis Ankylosing Spondylitis Ankylosing spondylitis is the prototypical spondyloarthropathy and a systemic disorder characterized by inflammation of the axial skeleton, large peripheral joints, and digits; nocturnal back... read more Ankylosing Spondylitis , reactive arthritis Reactive Arthritis Reactive arthritis is an acute spondyloarthropathy that often seems precipitated by an infection, usually genitourinary or gastrointestinal. Common manifestations include asymmetric arthritis... read more Reactive Arthritis , psoriatic arthritis Psoriatic Arthritis Psoriatic arthritis is a spondyloarthropathy and chronic inflammatory arthritis that occurs in people with psoriasis of the skin or nails. The arthritis is often asymmetric, and some forms involve... read more Psoriatic Arthritis , and other disorders.

Juvenile-onset spondyloarthropathy is an asymmetric, mostly lower extremity spondyloarthropathy that begins most commonly in boys aged 7 to 16.

Spondyloarthropathy can also develop in people without characteristics of other specific spondyloarthropathies (undifferentiated spondyloarthropathy). Treatment of the arthritis of these other spondyloarthropathies is similar to the treatment of reactive arthritis Treatment Reactive arthritis is an acute spondyloarthropathy that often seems precipitated by an infection, usually genitourinary or gastrointestinal. Common manifestations include asymmetric arthritis... read more Treatment .

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Ankylosing Spondylitis
Which of the following is the most frequent initial manifestation of ankylosing spondylitis? 
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