Spinal vertebrae are separated by fibrocartilaginous disks consisting of an outer annulus fibrosus and an inner nucleus pulposus. When degenerative changes (with or without trauma) result in protrusion or rupture of the nucleus through the annulus fibrosus in the lumbosacral or cervical area, the nucleus is displaced posterolaterally or posteriorly into the extradural space.
Radiculopathy Nerve Root Disorders Nerve root disorders result in segmental radicular deficits (eg, pain or paresthesias in a dermatomal distribution, weakness of muscles innervated by the root). Diagnosis may require neuroimaging... read more occurs when the herniated nucleus compresses or irritates the nerve root. Posterior protrusion may compress the cord in the cervical, thoracic, or upper lumbar spine or the cauda equina, especially in a congenitally narrow spinal canal (spinal stenosis Lumbar Spinal Stenosis Lumbar spinal stenosis is narrowing of the lumbar spinal canal compresses the nerve rootlets and nerve roots in the cauda equina before their exit from the foramina. It causes positional back... read more 
). In the lumbar area, > 80% of disk ruptures affect L5 or S1 nerve roots; in the cervical area, C6 and C7 are most commonly affected.
Herniated disks are common.
Symptoms and Signs of Herniated Nucleus Pulposus
Herniated disks often cause no symptoms, or they may cause symptoms and signs in the distribution of affected nerve roots. Pain usually develops suddenly, and back pain is typically relieved by bed rest. In contrast, nerve root pain caused by an epidural tumor or abscess begins more insidiously, and back pain is worsened by bed rest.
Cauda equina compression often results in urine retention or incontinence due to loss of sphincter function.
In patients with lumbosacral herniation, straight-leg raises stretch the lower lumbar roots and exacerbate back or leg pain (bilateral if disk herniation is central); straightening the knee while sitting also causes pain.
Cervical herniation causes pain during neck flexion or tilting.
Diagnosis of Herniated Nucleus Pulposus
MRI or CT can identify the cause and precise level of the lesion. Rarely (ie, when MRI is contraindicated and CT is inconclusive), CT myelography is necessary. Electrodiagnostic testing may help identify the involved root.
Because an asymptomatic herniated disk is common, the clinician must carefully correlate symptoms with MRI abnormalities before invasive procedures are considered.
Treatment of Herniated Nucleus Pulposus
Because a herniated disk desiccates and shrinks over time, symptoms tend to abate regardless of treatment. Up to 85% of patients with back pain—regardless of cause—recover without surgery within 6 weeks.
Conservative treatment
Treatment of a herniated disk should be conservative, unless neurologic deficits are progressive or severe. Heavy or vigorous physical activity is restricted, but ambulation and light activity (eg, lifting objects < 2.5 to 5 kg [about 5 to 10 lb] using correct techniques) are permitted as tolerated; prolonged bed rest (including traction) is no longer indicated.
Acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), or other analgesics should be used as needed to relieve pain. If symptoms are not relieved with nonopioid analgesics, corticosteroids can be given systemically or as an epidural injection; however, analgesia tends to be modest and temporary. Oral methylprednisolone may be given, tapered over 6 days, starting with 24 mg daily and decreased by 4 mg a day.
Physical therapy and home exercises can improve posture and strengthen back muscles and thus reduce spinal movements that further irritate or compress the nerve root.
Invasive procedures
Invasive procedures should be considered for the following:
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Persistent or worsening neurologic deficits, particularly objective deficits (eg, weakness, reflex deficits) due to cervical or lumbar radiculopathies
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Acute compression of the spinal cord Spinal Cord Compression Various lesions can compress the spinal cord, causing segmental sensory, motor, reflex, and sphincter deficits. Diagnosis is by MRI. Treatment is directed at relieving compression. (See also... read more
or cauda equina syndrome Cauda Equina Syndrome Cauda equina syndrome occurs when the nerve roots at the caudal end of the cord are compressed or damaged, disrupting motor and sensory pathways to the lower extremities and bladder. (See also... read more -
Severe, intractable nerve root pain or sensory deficits
Immediate surgical evaluation is needed if clinical findings of spinal cord compression correlate with MRI abnormalities.
Microscopic diskectomy and laminectomy with surgical removal of herniated material are usually the procedures of choice. Percutaneous approaches to remove bulging disk material are still being evaluated.
Dissolving herniated disk material with local injections of the enzyme chymopapain is not recommended.
Lesions acutely compressing the spinal cord or cauda equina (eg, causing urine retention or incontinence) require immediate surgical evaluation (see diagnosis of spinal cord compression Diagnosis Various lesions can compress the spinal cord, causing segmental sensory, motor, reflex, and sphincter deficits. Diagnosis is by MRI. Treatment is directed at relieving compression. (See also... read more ).
If cervical radiculopathies are accompanied by signs of spinal cord compression, surgical decompression is needed immediately; otherwise, it is done electively when nonsurgical treatments are ineffective.
Key Points
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Herniated disks are common and usually affect nerve roots at C6, C7, L5, or S1.
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If symptoms develop suddenly and back pain is relieved with rest, suspect a herniated disk rather than an epidural tumor or abscess.
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Recommend analgesics, light activity as tolerated, and exercises to improve posture and strength; however, if pain or deficits are severe or worsening, consider invasive procedures.
