Merck Manual

Please confirm that you are a health care professional

honeypot link

Glossopharyngeal Neuralgia


Michael Rubin

, MDCM, New York Presbyterian Hospital-Cornell Medical Center

Reviewed/Revised Nov 2023

Glossopharyngeal neuralgia is characterized by recurrent attacks of severe pain in the 9th and 10th cranial nerve distribution (posterior pharynx, tonsils, back of the tongue, middle ear, under the angle of the jaw). Diagnosis is clinical. Treatment is usually with carbamazepine or gabapentin.

Glossopharyngeal neuralgia is rare, more commonly affecting men, usually after age 40.

Etiology of Glossopharyngeal Neuralgia

Rarely, the cause is a tumor in the cerebellopontine angle or the neck, a peritonsillar abscess, a carotid aneurysm, or a demyelinating disorder.

Often, no cause is identified.

Symptoms and Signs of Glossopharyngeal Neuralgia

As in trigeminal neuralgia, paroxysmal attacks of unilateral brief, excruciating pain occur spontaneously or are precipitated when areas innervated by the glossopharyngeal nerve are stimulated (eg, by chewing, swallowing, coughing, talking, yawning, or sneezing). The pain, lasting seconds to a few minutes, usually begins in the tonsillar region or at the base of the tongue and may radiate to the ipsilateral ear.

Occasionally, increased activation of the vagus nerve due to its connections with the glossopharyngeal nerve causes sinus arrest with syncope; episodes may occur daily or once every few weeks.

Diagnosis of Glossopharyngeal Neuralgia

  • Clinical evaluation, often including response to anesthetics

  • MRI

Diagnosis of glossopharyngeal neuralgia is clinical.

Glossopharyngeal neuralgia is distinguished from trigeminal neuralgia by the location of the pain. Also, in glossopharyngeal neuralgia, swallowing or touching the tonsils with an applicator tends to precipitate pain, and applying lidocaine to the throat temporarily eliminates spontaneous or evoked pain.

MRI is done to exclude tonsillar, pharyngeal, and cerebellopontine angle tumors and metastatic lesions in the anterior cervical triangle. X-rays or CT can be done to look for an elongated styloid process below the ear, which could be compressing the nerve.

Local nerve blocks done by an otolaryngologist can help distinguish between carotidynia, superior laryngeal neuralgia, and pain caused by tumors.

Treatment of Glossopharyngeal Neuralgia

  • Usually antiseizure drugs

Treatment of glossopharyngeal neuralgia is the same as that for trigeminal neuralgia Treatment Trigeminal neuralgia is severe paroxysmal, lancinating facial pain due to a disorder of the 5th cranial nerve. Diagnosis is clinical. Treatment is usually with carbamazepine or gabapentin; sometimes... read more (eg, carbamazepine, oxcarbazepine, lamotrigine, gabapentin, pregabalin, phenytoin, amitriptyline). Glossopharyngeal nerve block may be used initially for pain relief while waiting for an oral medication to take effect.

If oral drugs are ineffective, local anesthetics can provide relief. For example, topical cocaine applied to the pharynx may provide temporary relief. However, surgery to decompress the nerve from a pulsating artery (microvascular decompression) may be necessary. If pain is restricted to the pharynx, surgery can be restricted to the extracranial part of the nerve. If pain is widespread, surgery must involve the intracranial part of the nerve.

Key Points

  • The pain of glossopharyngeal neuralgia is similar to that of trigeminal neuralgia.

  • Distinguish glossopharyngeal neuralgia from trigeminal neuralgia based on the pain's location and response to touching and to lidocaine applied to the pharynx.

  • Do MRI to distinguish glossopharyngeal neuralgia from tumors and metastatic lesions.

  • Treat as for trigeminal neuralgia (usually with antiseizure drugs).

  • If drugs are ineffective, try local anesthetics, but microvascular decompression may be necessary.

Drugs Mentioned In This Article

Drug Name Select Trade
Carbatrol, Epitol , Equetro, Tegretol, Tegretol -XR
Active-PAC with Gabapentin, Gabarone , Gralise, Horizant, Neurontin
7T Lido, Akten , ALOCANE, ANASTIA, AneCream, Anestacon, Aspercreme with Lidocaine, Astero , BenGay, Blue Tube, Blue-Emu, CidalEaze, DermacinRx Lidogel, DermacinRx Lidorex, DERMALID, Ela-Max, GEN7T, Glydo, Gold Bond, LidaMantle, Lidocan, Lidocare, Lidoderm, LidoDose, LidoDose Pediatric, Lidofore, LidoHeal-90, LIDO-K , Lidomar , Lidomark, LidoReal-30, LidoRx, Lidosense 4 , Lidosense 5, Lidosol, Lidosol-50, LIDO-SORB, Lidotral, Lidovix L, LIDOZION, Lidozo, LMX 4, LMX 4 with Tegaderm, LMX 5, LTA, Lydexa, Moxicaine, Numbonex, ReadySharp Lidocaine, RectaSmoothe, RectiCare, Salonpas Lidocaine, Senatec, Solarcaine, SUN BURNT PLUS, Tranzarel, Xyliderm, Xylocaine, Xylocaine Dental, Xylocaine in Dextrose, Xylocaine MPF, Xylocaine Topical, Xylocaine Topical Jelly, Xylocaine Topical Solution, Xylocaine Viscous, Zilactin-L, Zingo, Zionodi, ZTlido
Oxtellar XR, Trileptal
Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR, Subvenite
Lyrica, Lyrica CR
Dilantin, Dilantin Infatabs, Dilantin-125, Phenytek
Elavil, Tryptanol, Vanatrip
NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
quiz link

Test your knowledge

Take a Quiz!