Merck Manual

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Drugs for Serious Fungal Infections

Drugs for Serious Fungal Infections

Drug

Common Uses

Some Side Effects

Amphotericin B

Most fungal infections

Chills, fever, headache, vomiting, a low potassium level* in the blood, kidney failure, and anemia

Anidulafungin

Caspofungin

Micafungin

Nausea, diarrhea, headache, liver inflammation, inflammation of the veins, and rash

Fluconazole

Nausea, rash, and liver inflammation

Flucytosine

Nausea, vomiting, and bone marrow damage

Isavuconazole

Nausea, vomiting, and liver inflammation

Itraconazole

Nausea, diarrhea, liver inflammation, rash, headache, dizziness, a low potassium level* in the blood, high blood pressure, accumulation of fluid (edema), and heart failure

SUBA-itraconazole

Nausea, diarrhea, liver inflammation, rash, headache, dizziness, a low potassium level* in the blood, high blood pressure, accumulation of fluid (edema), and heart failure

Posaconazole

Aspergillus Aspergillosis Aspergillosis , candidal Candidiasis Candidiasis , and many other fungal infections

Nausea, vomiting, rash, and liver inflammation

Voriconazole

Aspergillus Aspergillosis Aspergillosis and candidal Candidiasis Candidiasis infections, fusariosis, and scedosporiosis

Temporary disturbances in vision (such as blurred vision, changes in color vision, and sensitivity to light), nausea, vomiting, rash, and liver inflammation

* A low potassium level (hypokalemia) can cause muscle weakness, cramping, and twitches and abnormal heart rhythms.

Flucytosine is usually used with amphotericin B for serious Candida and cryptococcal infections.