Merck Manual

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Some Drugs That Interfere With Sleep

Some Drugs That Interfere With Sleep

Type

Examples

When the drug is used

Antiseizure drugs

Phenytoin

Chemotherapy drugs

All

Drugs that stimulate the brain

Amphetamines

Caffeine

Beta blockers

Propranolol

Steroids

Anabolic steroids

Corticosteroids

Thyroid hormone preparations

When the drug is stopped

Recreational drugs

Cocaine

Heroin

Marijuana

Phencyclidine

Drugs that slow the brain

Barbiturates

Opioids

Sedatives

When the drug is used or stopped

Alcohol

Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine

Serotonin- norepinephrine reuptake inhibitors, such as duloxetine

Monoamine oxidase inhibitors (MAOIs), such as selegiline

Tricyclic antidepressants, such as amitriptyline