Merck Manual

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Major Myeloproliferative Neoplasms

Major Myeloproliferative Neoplasms

Disorder

Bone Marrow Characteristics

Blood Characteristics

Increased number of mature and immature white cells

Increased number of a certain type of white blood cell (granulocytes)

Sometimes increased number of platelets

Increased number of cells that produce the circulating blood cells

Increased number of red blood cells

Usually, increased number of platelets, white blood cells, or both

Excess fibrous tissue replacing blood-producing cells

Decreased number of red blood cells (anemia) and an increased number of white blood cells

Misshapen red blood cells

The numbers of white blood cells and platelets often eventually decrease, but in some people they increase

Increased number of cells that produce platelets (megakaryocytes)

Increased number of platelets