Merck Manual

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Some Causes of Depression

Some Causes of Depression

Condition

Examples

Brain and nervous system disorders

Dementia (in early stages)

Seizures that affect the temporal lobe (complex partial seizures)

Cancers

Cancer spreading throughout the body (metastatic)

Connective tissue disorders

Hormonal disorders

High levels of parathyroid hormone (hyperparathyroidism)

Low or high levels of thyroid hormone (hypothyroidism or hyperthyroidism)

Low levels of pituitary hormones (hypopituitarism)

Low levels of testosterone (hypogonadism)

Infections

Syphilis (late stage)

Viral pneumonia

Mental disorders other than mood disorders

Dementia in the early stages

Nutritional disorders

Pellagra (vitamin B6 deficiency)

Pernicious anemia (a form of vitamin B12 deficiency)

Other disorders

Drugs

Amphotericin B

Beta-blockers (some)

Cimetidine

Contraceptives (oral)

Corticosteroids

Cycloserine

Hormone ( estrogen or progesterone) therapy

Interferon

Mercury

Methyldopa

Metoclopramide

Reserpine

Thallium

Vinblastine

Vincristine