Merck Manual

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Sulfonamides

Sulfonamides

Drug

Common Uses

Some Side Effects

Mafenide

Sulfacetamide

Sulfadiazine

Sulfadoxine

Sulfamethizole

Sulfanilamide

Sulfasalazine

Sulfisoxazole

Urinary tract infections (except sulfasalazine, sulfacetamide, and mafenide)

For sulfanilamide: Inflammation of the vagina (vaginitis)

For sulfasalazine:Inflammatory bowel disease

For sulfacetamide: Superficial eye infections

For mafenide and sulfadiazine: Only topically for burns

For trimethoprim/sulfamethoxazole: Skin infections caused by susceptible bacteria that are resistant to other antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA)

Nausea, vomiting, and diarrhea

Allergy (including rashes)

Crystals in urine (rare)

A decrease in white blood cell and platelet counts

Sensitivity to sunlight

Possibly increased tendency to bleed if used with warfarin

In people with G6PD deficiency (see table More About Some Causes of Anemia), the breakdown of red blood cells

G6PD = deficiency of glucose-6-phosphate dehydrogenase.