Merck Manual

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Sulfonamides

Sulfonamides

Drug

Common Uses

Some Side Effects

Mafenide

Sulfacetamide

Sulfadiazine

Sulfadoxine

Sulfamethizole

Sulfanilamide

Sulfasalazine

Sulfisoxazole

For sulfacetamide: Superficial eye infections

For mafenide and sulfadiazine: Only topically for burns

For trimethoprim/sulfamethoxazole: Skin infections caused by susceptible bacteria that are resistant to other antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA Methicillin-resistant Staphylococcus aureus (MRSA) Staphylococcus aureus is the most dangerous of all of the many common staphylococcal bacteria. These gram-positive, sphere-shaped (coccal) bacteria (see figure How Bacteria Shape Up) often cause... read more Methicillin-resistant Staphylococcus aureus (MRSA) )

Nausea, vomiting, and diarrhea

Crystals in urine (rare)

A decrease in white blood cell and platelet counts

Sensitivity to sunlight

Possibly increased tendency to bleed if used with warfarin

G6PD = deficiency of glucose-6-phosphate dehydrogenase.