Merck Manual

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Some Causes and Features of Diarrhea

Some Causes and Features of Diarrhea


Common Features*


Acute diarrhea (lasting less than 2 weeks)

Antibiotic use

Recent use of antibiotics

Often no other symptoms

A doctor’s examination

Sometimes tests for Clostridium difficile toxin in stool

Often with vomiting

Dehydration common especially among infants and young children

Sometimes fever and abdominal pain

Rarely blood in stool

Sometimes recent contact with infected people (such as those at a day care center, at a camp, or on a cruise), with animals at a petting zoo (where Escherichia [E.] coli may be acquired), or with reptiles (which may be infected with Salmonella bacteria) or recent consumption of undercooked, contaminated food or contaminated water

A doctor’s examination

Sometimes examination and testing of stool

Hives, swelling of the lips, and difficulty breathing within minutes to several hours after eating

Sometimes vomiting

Often an already identified food allergy

A doctor’s examination

Abdominal pain, vomiting, and usually bloody diarrhea for a few days, followed by development of pale skin and decreased urination

Sometimes bleeding in the skin (seen as tiny reddish purple dots or splotches)

Blood tests

Examination and testing of stool

Chronic diarrhea (lasting 2 weeks or more)


Poor feeding

Weight loss, poor growth, or both

Blood in stools

Stool tests

Symptoms that lessen when the formula is changed

Possibly endoscopy, colonoscopy, or both

Excessive consumption of fruit juices (especially apple, pear, and prune)

Drinking more than 4–8 ounces of fruit juice a day

Often no other symptoms except diarrhea

A doctor’s examination

Resolution of diarrhea after decreasing consumption of fruit juices

Blood in stool, crampy abdominal pain, weight loss, loss of appetite, and poor growth

Sometimes arthritis, rashes, sores in the mouth, and tears in the rectum


Sometimes CT or x-rays after barium is inserted in the rectum (barium enema)

Abdominal bloating, passing of gas (flatulence), and explosive diarrhea

Diarrhea after consumption of milk and dairy products

A doctor’s examination

Sometimes a breath test to detect hydrogen (indicates undigested carbohydrates)

Examination and analysis of stool to check for unabsorbed carbohydrates

Malabsorption disorders such as

Light-colored, soft, bulky, and unusually foul-smelling stool that may appear oily

Abdominal bloating and flatulence

Poor weight gain

With cystic fibrosis, frequent respiratory infections

With acrodermatitis enteropathica, rash and cracks in the corners of the mouth

Examination and testing of stool

If celiac disease is suspected, blood tests to measure antibodies against gluten (a protein in wheat) and biopsy of the small intestine

If cystic fibrosis is suspected, a sweat test and possibly genetic testing

If acrodermatitis enteropathica is suspected, a blood test for zinc deficiency

A weakened immune system due to

Frequent infections

Weight loss or poor weight gain

Sometimes an already identified HIV infection

Blood tests for HIV

A complete blood cell count and other blood tests to evaluate the immune system

* Features include symptoms and results of the doctor's examination. Features mentioned are typical but not always present.

† Infections by bacteria, parasites, or viruses can also cause chronic diarrhea.

CT = computed tomography; HIV = human immunodeficiency virus.