Merck Manual

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Common Uses

Some Potential Side Effects


Complicated skin infections, bloodstream infections, and certain heart valve infections ( endocarditis Infective Endocarditis Infective Endocarditis ) due to susceptible bacteria, including methicillin-resistant Staphylococcus aureus ( MRSA Methicillin-resistant Staphylococcus aureus (MRSA) Staphylococcus aureus is the most dangerous of all of the many common staphylococcal bacteria. These gram-positive, sphere-shaped (coccal) bacteria (see figure How Bacteria Shape Up)... read more Methicillin-resistant <i > Staphylococcus aureus </i> (MRSA) ) and vancomycin-resistant enterococci

Increased number of white blood cells in the lungs ( eosinophilic pneumonia Eosinophilic Pneumonia )

Gastrointestinal upset

Muscle pain and weakness

Not used when infection involves the lungs because daptomycin is made inactive by surfactant (a substance normally produced in the lungs)