Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

Paget Disease of Bone

By

The Manual's Editorial Staff

Medically Reviewed Aug 2021 | Modified Sep 2022
VIEW PROFESSIONAL VERSION
Get the full details

Bones are constantly breaking down and rebuilding, a process known as remodeling. In this process, old bone tissue is gradually replaced by new bone tissue.

What is Paget disease of bone?

Paget disease of bone is a problem with the way your bone cells break down and rebuild (remodel). Parts of some of your bones grow thicker but weaker than normal.

What causes Paget disease of bone?

Bone is living tissue that is constantly being broken down and rebuilt. In Paget disease of bone, something goes wrong with how bone cells break down and are rebuilt. This leads to bone that grows bigger than normal but is weak.

Most of the time, doctors don’t know what causes this to happen. Paget disease can run in families.

What are the symptoms of Paget disease of bone?

Paget disease usually causes no symptoms. If you do have symptoms, you may have:

How can doctors tell if I have Paget disease of bone?

How do doctors treat Paget disease of bone?

Doctors will treat your Paget disease of bone if you have pain or they think it may cause other problems, such as hearing loss, osteoarthritis, or a misshapen body part. Usually they will:

  • Have you take pain medicine (such as acetaminophen) to lessen pain

  • Have you take calcium and vitamin D to strengthen your bones

  • Encourage you to do daily activities that help build strong bones, such as standing and walking

  • If one leg becomes curved and shortened, have you wear a shoe insert

  • Sometimes, do surgery to relieve pinched nerves or replace a damaged joint

  • Take medicines called bisphosphonates, which affect the abnormal bone growth

Drugs Mentioned In This Article

Generic Name Select Brand Names
7T Gummy ES, Acephen, Aceta, Actamin, Adult Pain Relief, Anacin Aspirin Free, Apra, Children's Acetaminophen, Children's Pain & Fever , Comtrex Sore Throat Relief, ED-APAP, ElixSure Fever/Pain, Feverall, Genapap, Genebs, Goody's Back & Body Pain, Infantaire, Infants' Acetaminophen, LIQUID PAIN RELIEF, Little Fevers, Little Remedies Infant Fever + Pain Reliever, Mapap, Mapap Arthritis Pain, Mapap Infants, Mapap Junior, M-PAP, Nortemp, Ofirmev, Pain & Fever , Pain and Fever , PAIN RELIEF , PAIN RELIEF Extra Strength, Panadol, PediaCare Children's Fever Reducer/Pain Reliever, PediaCare Children's Smooth Metls Fever Reducer/Pain Reliever, PediaCare Infant's Fever Reducer/Pain Reliever, Pediaphen, PHARBETOL, Plus PHARMA, Q-Pap, Q-Pap Extra Strength, Silapap, Triaminic Fever Reducer and Pain Reliever, Triaminic Infant Fever Reducer and Pain Reliever, Tylenol, Tylenol 8 Hour, Tylenol 8 Hour Arthritis Pain, Tylenol 8 Hour Muscle Aches & Pain, Tylenol Arthritis Pain, Tylenol Children's, Tylenol Children's Pain+Fever, Tylenol CrushableTablet, Tylenol Extra Strength, Tylenol Infants', Tylenol Infants Pain + Fever, Tylenol Junior Strength, Tylenol Pain + Fever, Tylenol Regular Strength, Tylenol Sore Throat, XS No Aspirin, XS Pain Reliever
Calcidol, Calciferol, D3 Vitamin, DECARA, Deltalin, Dialyvite Vitamin D, Dialyvite Vitamin D3, Drisdol, D-Vita, Ergo D, Fiber with Vitamin D3 Gummies Gluten-Free, Happy Sunshine Vitamin D3, MAXIMUM D3, PureMark Naturals Vitamin D, Replesta, Replesta Children's, Super Happy SUNSHINE Vitamin D3, Thera-D 2000, Thera-D 4000, Thera-D Rapid Repletion, THERA-D SPORT, UpSpring Baby Vitamin D, UpSpring Baby Vitamin D3
NOTE: This is the Consumer Version. DOCTORS: VIEW PROFESSIONAL VERSION
VIEW PROFESSIONAL VERSION
quiz link

Test your knowledge

Take a Quiz!
iOS ANDROID
iOS ANDROID
iOS ANDROID
TOP