Varicose veins may occur alone or with chronic venous insufficiency Chronic Venous Insufficiency and Postphlebitic Syndrome Chronic venous insufficiency is impaired venous return, sometimes causing lower extremity discomfort, edema, and skin changes. Postphlebitic (postthrombotic) syndrome is symptomatic chronic... read more , and also can develop after deep venous thrombosis.
Etiology of Varicose Veins
Etiology is usually unknown, but varicose veins may result from primary venous valvular insufficiency with reflux or from primary dilation of the vein wall due to structural weakness. In some people, varicose veins result from chronic venous insufficiency and venous hypertension. Most people have no obvious risk factors. Varicose veins are common within families, suggesting a genetic component. Varicose veins are more common among women because estrogen affects venous structure, pregnancy increases pelvic and leg venous pressures, or both. Rarely, varicose veins are part of Klippel-Trénaunay-Weber syndrome, which includes congenital arteriovenous fistulas Arteriovenous Fistula An arteriovenous fistula is an abnormal communication between an artery and a vein. An arteriovenous fistula may be congenital (usually affecting smaller vessels) or acquired as a result of... read more and diffuse cutaneous capillary angiomas.
Symptoms and Signs of Varicose Veins
Varicose veins may initially be tense and palpable but are not necessarily visible. Later, they may progressively enlarge, protrude, and become obvious; they can cause a sense of fullness, fatigue, pressure, and superficial pain or hyperesthesia in the legs. Varicose veins are most visible when the patient stands.
For unclear reasons, stasis dermatitis and venous stasis ulcers are uncommon. When skin changes (eg, induration, pigmentation, eczema) occur, they typically affect the medial malleolar region. Ulcers may develop after minimal trauma to an affected area; they are usually small, superficial, and painful.
Varicose veins occasionally thrombose, causing pain. Superficial varicose veins may cause thin venous bullae in the skin, which may rupture and bleed after minimal trauma. Very rarely, such bleeding, if undetected during sleep, is fatal.
Pearls & Pitfalls
Diagnosis of Varicose Veins
Sometimes Doppler ultrasonography
Diagnosis is usually obvious from the physical examination. Trendelenburg test (comparing venous filling before and after release of a thigh tourniquet) is no longer commonly used to identify retrograde blood flow past incompetent saphenous valves.
Duplex ultrasonography is an accurate test, but it is not clear whether it is routinely necessary.
Treatment of Varicose Veins
Sometimes minimally invasive therapy (eg, sclerotherapy, thermal ablation) or surgery
Treatment aims to relieve symptoms, improve the leg’s appearance, and, in some cases, prevent complications of varicose veins. Treatment includes compression stockings and local wound care as needed.
Minimally invasive therapy (eg, sclerotherapy) and surgery are indicated for prevention of recurrent variceal thrombosis and for skin changes; these procedures are also commonly used for cosmetic reasons.
Sclerotherapy uses an irritant (eg, sodium tetradecyl sulfate) to induce a thrombophlebitic reaction that fibroses and occludes the vein; however, many varicose veins recannulate. Surgery involves ligation or stripping of the long and sometimes the short saphenous veins. These procedures provide good short-term symptom relief, but long-term efficacy is poor (ie, patients often develop recurrent varicose veins).
Thermal ablation with the use of laser or radiofrequency ablation is another minimally invasive tool for the treatment of varicose veins.
Regardless of treatment, new varicose veins develop, and treatment often must be repeated indefinitely.
Varicose veins are more common in women than in men.
Symptoms may include fullness, fatigue, pressure, bleeding and pain or hyperesthesia in the legs; stasis dermatitis and venous stasis ulcers are uncommon.
Treatment may include compression stockings, sclerotherapy, minimally invasive surgery, or thermal ablation
Regardless of treatment, varicose veins often recur.
Drugs Mentioned In This Article
|Drug Name||Select Trade|
sodium tetradecyl sulfate