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Sepsis and Septic Shock

By

Paul M. Maggio

, MD, MBA, Stanford University Medical Center

Last full review/revision Jan 2020| Content last modified Jan 2020
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Topic Resources

Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection. In septic shock, there is critical reduction in tissue perfusion; acute failure of multiple organs, including the lungs, kidneys, and liver, can occur. Common causes in immunocompetent patients include many different species of gram-positive and gram-negative bacteria. Immunocompromised patients may have uncommon bacterial or fungal species as a cause. Signs include fever, hypotension, oliguria, and confusion. Diagnosis is primarily clinical combined with culture results showing infection; early recognition and treatment is critical. Treatment is aggressive fluid resuscitation, antibiotics, surgical excision of infected or necrotic tissue and drainage of pus, and supportive care.

Sepsis represents a spectrum of disease with mortality risk ranging from moderate (eg, 10%) to substantial (eg, > 40%) depending on various pathogen and host factors along with the timeliness of recognition and provision of appropriate treatment.

Septic shock is a subset of sepsis with significantly increased mortality due to severe abnormalities of circulation and/or cellular metabolism. Septic shock involves persistent hypotension (defined as the need for vasopressors to maintain mean arterial pressure ≥ 65 mm Hg, and a serum lactate level > 18 mg/dL [2 mmol/L] despite adequate volume resuscitation [1]).

The concept of the systemic inflammatory response syndrome (SIRS), defined by certain abnormalities of vital signs and laboratory results, has long been used to identify early sepsis. However, SIRS criteria have been found to lack sensitivity and specificity for increased mortality risk, which is the main consideration for using such a conceptual model. The lack of specificity may be because the SIRS response is often adaptive rather than pathologic.

General reference

Etiology

Most cases of septic shock are caused by hospital-acquired gram-negative bacilli or gram-positive cocci and often occur in immunocompromised patients and patients with chronic and debilitating diseases. Rarely, it is caused by Candida or other fungi. A postoperative infection (deep or superficial) should be suspected as the cause of septic shock in patients who have recently had surgery. A unique, uncommon form of shock caused by staphylococcal and streptococcal toxins is called toxic shock syndrome.

Septic shock occurs more often in neonates (see Neonatal Sepsis), the elderly, and pregnant women. Predisposing factors include

  • Leukopenia (especially that associated with cancer or treatment with cytotoxic drugs)

  • Invasive devices (including endotracheal tubes, vascular or urinary catheters, drainage tubes, and other foreign materials)

  • Prior treatment with antibiotics or corticosteroids

Common causative sites of infection include the lungs and the urinary, biliary, and gastrointestinal tracts.

Pathophysiology

The pathogenesis of septic shock is not completely understood. An inflammatory stimulus (eg, a bacterial toxin) triggers production of proinflammatory mediators, including tumor necrosis factor (TNF) and interleukin (IL)-1. These cytokines cause neutrophil–endothelial cell adhesion, activate the clotting mechanism, and generate microthrombi. They also release numerous other mediators, including leukotrienes, lipoxygenase, histamine, bradykinin, serotonin, and IL-2. They are opposed by anti-inflammatory mediators, such as IL-4 and IL-10, resulting in a negative feedback mechanism.

Initially, arteries and arterioles dilate, decreasing peripheral arterial resistance; cardiac output typically increases. This stage has been referred to as warm shock. Later, cardiac output may decrease, blood pressure falls (with or without an increase in peripheral resistance), and typical features of shock appear.

Even in the stage of increased cardiac output, vasoactive mediators cause blood flow to bypass capillary exchange vessels (a distributive defect). Poor capillary flow resulting from this shunting, along with capillary obstruction by microthrombi, decreases delivery of oxygen and impairs removal of carbon dioxide and waste products. Decreased perfusion causes dysfunction and sometimes failure of one or more organs, including the kidneys, lungs, liver, brain, and heart.

Coagulopathy may develop because of intravascular coagulation with consumption of major clotting factors, excessive fibrinolysis in reaction thereto, and more often a combination of both.

Symptoms and Signs

Symptoms and signs of sepsis can be subtle and often easily mistaken for manifestations of other disorders (eg, delirium, primary cardiac dysfunction, pulmonary embolism), especially in postoperative patients. With sepsis, patients typically have fever, tachycardia, diaphoresis, and tachypnea; blood pressure remains normal. Other signs of the causative infection may be present. As sepsis worsens or septic shock develops, an early sign, particularly in older people or the very young, may be confusion or decreased alertness. Blood pressure decreases, yet the skin is paradoxically warm. Later, extremities become cool and pale, with peripheral cyanosis and mottling. Organ dysfunction causes additional symptoms and signs specific to the organ involved (eg, oliguria, dyspnea).

Diagnosis

  • Clinical manifestations

  • Blood pressure (BP), heart rate, and oxygen monitoring

  • Complete blood count (CBC) with differential, electrolyte panel and creatinine, lactate

  • Invasive central venous pressure (CVP), PaO2, and central venous oxygen saturation (ScvO2) readings

  • Cultures of blood, urine, and other potential sites of infection, including wounds in surgical patients

Sepsis is suspected when a patient with a known infection develops systemic signs of inflammation or organ dysfunction. Similarly, a patient with otherwise unexplained signs of systemic inflammation should be evaluated for infection by history, physical examination, and tests, including urinalysis and urine culture (particularly in patients who have indwelling catheters), blood cultures, and cultures of other suspect body fluids. In patients with a suspected surgical or occult cause of sepsis, ultrasonography, CT, or MRI may be required, depending on the suspected source. Blood levels of C-reactive protein and procalcitonin are often elevated in severe sepsis and may facilitate diagnosis, but they are not specific. Ultimately, the diagnosis is clinical.

Other causes of shock (eg, hypovolemia, myocardial infarction [MI]) should be ruled out via history, physical examination, ECG, and serum cardiac markers. Even in the absence of MI, hypoperfusion caused by sepsis may result in ECG findings of cardiac ischemia including nonspecific ST-T wave abnormalities, T-wave inversions, and supraventricular and ventricular arrhythmias.

It is important to detect organ dysfunction as early as possible. A number of scoring systems have been devised, but the sequential organ failure assessment score (SOFA score) and the quick SOFA score (qSOFA) have been validated with respect to mortality risk and are relatively simple to use. The quick SOFA score is based on the blood pressure, respiratory rate, and the Glasgow coma scale and does not require waiting for lab results. For patients with a suspected infection who are not in the intensive care unit (ICU), the qSOFA score is a better predictor of inpatient mortality than the systemic inflammatory response syndrome (SIRS) and SOFA score. For patients with a suspected infection who are in the intensive care unit (ICU), the SOFA score is a better predictor of in-patient mortality than the systemic inflammatory response syndrome (SIRS) and qSOFA score (1).

Patients with ≥ 2 of the following criteria meet criteria for SIRS and should have further clinical and laboratory investigation:

  • Temperature > 38° C (100.4° F) or < 36° C 96.8° F

  • Heart rate > 90 beats per minute

  • Respiratory rate > 20 breaths per minute or PaCO2 < 32 mm Hg

  • White blood cell count > 12,000/mcL (12 X 109/L), < 4,000/mcL (4 X 109/L or > 10% immature (band) forms

Patients with ≥ 2 of the following qSOFA criteria should have further clinical and laboratory investigation:

  • Respiratory rate ≥ 22 breaths per minute

  • Altered mentation

  • Systolic blood pressure ≤ 100 mm Hg

The SOFA score is somewhat more robust in the ICU setting, but requires laboratory testing (see table Sequential Organ Failure Assessment Score).

Table
icon

Sequential Organ Failure Assessment (SOFA) Score

Parameter

Score: 0

Score: 1

Score: 2

Score: 3

Score: 4

PaO2/FIO2

≥ 400 mm Hg (53.3 kPa)

< 400 mm Hg (53.3 kPa)

< 300 mm Hg (40 kPa)

< 200 mm Hg (26.7 kPa) with respiratory support

< 100 mm Hg (13.3 kPa) with respiratory support

Platelets

≥ 150 × 103/mcL (≥ 150 × 109/L)

< 150 × 103/mcL (< 150 × 109/L)

< 100 × 103/mcL (< 100 × 109/L)

< 50 × 103/mcL (< 50 × 109/L)

< 20 × 103/mcL (< 20 × 109/L)

Bilirubin

≥ 1.2 mg/dL (20 micromole/L)

1.2–1.9 mg/dL (20–32 micromole/L)

2.0–5.9 mg/dL (33–101 micromole/L)

6.0–11.9 mg/dL (102–204 micromole/L)

> 12.0 mg/dL (204 micromole/L)

Cardiovascular

MAP ≥ 70 mm Hg

MAP < 70 mm Hg

Dopamine < 5 mcg/kg/minute for ≥ 1 hour

or

Any dose of dobutamine

Dopamine 5.1–15 mcg/kg/minute for ≥ 1 hour

or

Epinephrine ≤ 0.1 mcg/kg/minute for ≥ 1 hour

or

Norepinephrine ≤ 0.1 mcg/kg/minute for ≥ 1 hour

Dopamine > 15 mcg/kg/minute for ≥ 1 hour

or

Epinephrine > 0.1 mcg/kg/minute for ≥ 1 hour

or

Norepinephrine > 0.1 mcg/kg/minute for ≥ 1 hour

15 points

13–14 points

10–12 points

6–9 points

< 6 points

Creatinine

< 1.2 mg/dL (110 micromole/L)

1.2-1.9 mg/dL (110–170 micromole/L)

2.0-3.4 mg/dL (171–299 micromole/L)

3.5-4.9 mg/dL (300–400 micromole/L)

> 5.0 mg/dL (440 micromole/L)

Urine output

< 500 mL/day

< 200 mL/day

* A higher score indicates better neurologic function.

FIO2 = fractional inspired oxygen; kPa = kilopascals; MAP = mean arterial pressure; PaO2 = arterial oxygen partial pressure.

Adapted from Singer M, Deutschman CS, Seymour CW, et al: The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:801–810, 2016.

CBC, arterial blood gases (ABGs), chest x-ray, serum electrolytes, BUN (blood urea nitrogen), creatinine, PCO2, and liver function are monitored. Serum lactate levels, central venous oxygen saturation (ScvO2), or both can be done to help guide treatment. White blood cell (WBC) count may be decreased (< 4,000/mcL [< 4 × 109/L]) or increased (> 15,000/mcL [> 15 × 109/L]), and polymorphonuclear leukocytes may be as low as 20%. During the course of sepsis, the WBC count may increase or decrease, depending on the severity of sepsis or shock, the patient's immunologic status, and the etiology of the infection. Concurrent corticosteroid use may elevate WBC count and thus mask WBC changes due to trends in the illness.

Hyperventilation with respiratory alkalosis (low PaCO2 and increased arterial pH) occurs early, in part as compensation for lactic acidemia. Serum bicarbonate is usually low, and serum and blood lactate levels increase. As shock progresses, metabolic acidosis worsens, and blood pH decreases. Early hypoxemic respiratory failure leads to a decreased PaO2:FIO2 ratio and sometimes overt hypoxemia with PaO2< 70 mm Hg. Diffuse infiltrates may appear on the chest x-ray due to acute respiratory distress syndrome (ARDS). BUN and creatinine usually increase progressively as a result of renal insufficiency. Bilirubin and transaminases may rise, although overt hepatic failure is uncommon in patients with normal baseline liver function.

Many patients with severe sepsis develop relative adrenal insufficiency (ie, normal or slightly elevated baseline cortisol levels that do not increase significantly in response to further stress or exogenous adrenocorticotropic hormone [ACTH]). Adrenal function may be tested by measuring serum cortisol at 8 AM; a level < 5 mcg/dL (< 138 nmol/L) is inadequate. Alternatively, cortisol can be measured before and after injection of 250 mcg of synthetic ACTH; a rise of < 9 mcg/dL (< 248 nmol/L) is considered insufficient. However, in refractory septic shock, no cortisol testing is required before starting corticosteroid therapy.

Hemodynamic measurements with a central venous or pulmonary artery catheter can be used when the specific type of shock is unclear or when large fluid volumes (eg, > 4 to 5 L 0.9% saline within 6 to 8 hours) are needed.

Bedside echocardiography in the ICU is a practical and noninvasive alternative method of hemodynamic monitoring. In septic shock, cardiac output is increased and peripheral vascular resistance is decreased, whereas in other forms of shock, cardiac output is typically decreased and peripheral resistance is increased.

Neither CVP nor pulmonary artery occlusive pressure (PAOP) is likely to be abnormal in septic shock, unlike in hypovolemic, obstructive, or cardiogenic shock.

Diagnosis reference

  • 1. Seymour CW, Liu VX, Iwashyna TJ, et al: Assessment of clinical criteria for sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 215(8):762–774, 2016.

Prognosis

Overall mortality in patients with septic shock is decreasing and now averages 30 to 40% (range 10 to 90%, depending on patient characteristics). Poor outcomes often follow failure to institute early aggressive therapy (eg, within 6 hours of suspected diagnosis). Once severe lactic acidosis with decompensated metabolic acidosis becomes established, especially in conjunction with multiorgan failure, septic shock is likely to be irreversible and fatal. Mortality can be estimated with different scores including the MEDS score. The multiple organ dysfunction score measures dysfunction of 6 organ systems and correlates strongly with risk of mortality.

Treatment

  • Perfusion restored with IV fluids and sometimes vasopressors

  • Oxygen support

  • Broad-spectrum antibiotics

  • Source control

  • Sometimes other supportive measures (eg, corticosteroids, insulin)

Patients with septic shock should be treated in an ICU. The following should be monitored hourly:

  • CVP, PAOP, or ScvO2

  • Pulse oximetry

  • ABGs

  • Blood glucose, lactate, and electrolyte levels

  • Renal function

Urine output, a good indicator of renal perfusion, should be measured (in general, indwelling urinary catheters should be avoided unless they are essential). The onset of oliguria (eg, < about 0.5 mL/kg/hour) or anuria, or rising creatinine may signal impending renal failure.

Following evidence-based guidelines and formal protocols for timely diagnosis and treatment of sepsis has been shown to decrease mortality and length of stay in the hospital (1).

Perfusion restoration

IV fluids are the first method used to restore perfusion. Isotonic crystalloid (eg, 0.9% saline) is preferred. Some clinicians add albumin to the initial fluid bolus in patients with severe sepsis or septic shock; albumin is more expensive than crystalloid but is generally a safe complement to crystalloid. Starch-based fluids (eg, hydroxyethyl starch) are associated with increased mortality and should not be used.

Initially, 1 L of crystalloid is given rapidly. Most patients require a minimum of 30 mL/kg in the first 4 to 6 hours. However, the goal of therapy is not to administer a specific volume of fluid but to achieve tissue reperfusion without causing pulmonary edema due to fluid overload.

Estimates of successful reperfusion include ScvO2 and lactate clearance (ie, percent change in serum lactate levels). Target ScvO2 is ≥ 70%. Lactate clearance target is 10 to 20%. Risk of pulmonary edema can be controlled by optimizing preload; fluids should be given until CVP reaches 8 mm Hg (10 cm water) or PAOP reaches 12 to 15 mm Hg; however, patients on mechanical ventilation may require higher CVP levels. The quantity of fluid required often far exceeds the normal blood volume and may reach 10 L over 4 to 12 hours. PAOP or echocardiography can identify limitations in left ventricular function and incipient pulmonary edema due to fluid overload.

If a patient with septic shock remains hypotensive after CVP or PAOP has been raised to target levels, norepinephrine (highly individualized dosing) or vasopressin (up to 0.03 units/minute) may be given to increase mean BP to at least 65 mm Hg. Epinephrine may be added if a second drug is needed. However, vasoconstriction caused by higher doses of these drugs may cause organ hypoperfusion and acidosis.

Oxygen support

Oxygen is given by mask or nasal prongs. Tracheal intubation and mechanical ventilation may be needed subsequently for respiratory failure (see Mechanical ventilation in ARDS).

Antibiotics

Parenteral antibiotics should be given as soon as possible after specimens of blood, body fluids, and wound sites have been taken for Gram stain and culture. Very prompt empiric therapy, started immediately after suspecting sepsis, is essential and may be lifesaving. Antibiotic selection requires an educated guess based on the suspected source (eg, pneumonia, urinary tract infection), clinical setting, knowledge or suspicion of causative organisms and of sensitivity patterns common to that specific inpatient unit or institution, and previous culture results.

Typically, broad-spectrum gram-positive and gram-negative bacterial coverage is used initially; immunocompromised patients should also receive an empiric antifungal drug. There are many possible starting regimens; when available, institutional trends for infecting organisms and their antibiotic susceptibility patterns (antibiograms) should be used to select empiric treatment. In general, common antibiotics for empiric gram-positive coverage include vancomycin and linezolid. Empiric gram-negative coverage has more options and includes broad-spectrum penicillins (eg, piperacillin/tazobactam), 3rd- or 4th-generation cephalosporins, imipenems, and aminoglycosides. Initial broad coverage is narrowed based on culture and sensitivity data.

Pearls & Pitfalls

  • Knowledge of institution- and care unit–specific trends in infecting organisms and their antimicrobial sensitivity is an important guide to empiric antibiotic selection.

Source control

The source of infection should be controlled as early as possible. IV and urinary catheters and endotracheal tubes should be removed if possible or changed. Abscesses must be drained, and necrotic and devitalized tissues (eg, gangrenous gallbladder, necrotizing soft-tissue infection) must be surgically excised. If excision is not possible (eg, because of comorbidities or hemodynamic instability), surgical drainage may help. If the source is not controlled, the patient’s condition will continue to deteriorate despite antibiotic therapy.

Other supportive measures

Normalization of blood glucose improves outcome in critically ill patients, even those not known to be diabetic, because hyperglycemia impairs the immune response to infection. A continuous IV insulin infusion (starting dose 1 to 4 units/hour) is titrated to maintain glucose between 110 and 180 mg/dL (7.7 to 9.9 mmol/L). This approach necessitates frequent (eg, every 1 to 4 hours) glucose measurement.

Corticosteroid therapy may be beneficial in patients who remain hypotensive despite treatment with IV fluids, source control, antibiotics, and vasopressors. There is no need to measure cortisol levels before starting therapy. Treatment is with replacement rather than pharmacologic doses. One regimen consists of hydrocortisone 50 mg IV every 6 hours (or 100 mg every 8 hours). Continued treatment is based on patient response.

Treatment reference

Key Points

  • Sepsis and septic shock are increasingly severe clinical syndromes of life-threatening organ dysfunction caused by a dysregulated response to infection.

  • An important component is critical reduction in tissue perfusion, which can lead to acute failure of multiple organs, including the lungs, kidneys, and liver.

  • Early recognition and treatment is the key to improved survival.

  • Resuscitate with intravenous fluids and sometimes vasopressors titrated to optimize central venous oxygen saturation (ScvO2) and preload, and to lower serum lactate levels.

  • Control the source of infection by removing catheters, tubes, and infected and/or necrotic tissue and by draining abscesses.

  • Give empiric broad-spectrum antibiotics directed at most likely organisms and switch quickly to more specific drugs based on culture and sensitivity results.

Drugs Mentioned In This Article

Drug Name Select Trade
ZOSYN
LEVOPHED
CORTEF, SOLU-CORTEF
ADRENALIN
VASOSTRICT
No US brand name
VANCOCIN
ZYVOX
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