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Dyspepsia is a sensation of pain or discomfort in the upper abdomen; it often is recurrent. It may be described as indigestion, gassiness, early satiety, postprandial fullness, gnawing, or burning.
There are several common causes of dyspepsia (see Table: Some Causes of Dyspepsia).
Some Causes of Dyspepsia
Many patients have findings on testing (eg, duodenitis, pyloric dysfunction, motility disturbance, Helicobacter pylori gastritis, lactose deficiency, cholelithiasis) that correlate poorly with symptoms (ie, correction of the condition does not alleviate dyspepsia).
Nonulcer (functional) dyspepsia is defined as dyspeptic symptoms in a patient who has no abnormalities on physical examination and upper GI endoscopy.
History of present illness should elicit a clear description of the symptoms, including whether they are acute or chronic and recurrent. Other elements include timing and frequency of recurrence, any difficulty swallowing, and relationship of symptoms to eating or taking drugs. Factors that worsen symptoms (particularly exertion, certain foods, or alcohol) or relieve them (particularly eating or taking antacids) are noted.
Review of systems seeks concomitant GI symptoms such as anorexia, nausea, vomiting, hematemesis, weight loss, and bloody or black (melanotic) stools. Other symptoms include dyspnea and diaphoresis.
Past medical history should include known GI and cardiac diagnoses, cardiac risk factors (eg, hypertension, hypercholesterolemia), and the results of previous tests that have been done and treatments that have been tried. Drug history should include prescription and illicit drug use as well as alcohol.
Some findings are helpful (see Table: Some Causes of Dyspepsia).
A patient presenting with a single, acute episode of dyspepsia is of concern, particularly if symptoms are accompanied by dyspnea, diaphoresis, or tachycardia; such patients may have acute coronary ischemia. Chronic symptoms that occur with exertion and are relieved by rest may represent angina.
GI causes are most likely to manifest as chronic complaints. Symptoms are sometimes classified as ulcer-like, dysmotility-like, or reflux-like; these classifications suggest but do not confirm an etiology. Ulcer-like symptoms consist of pain that is localized in the epigastrium, frequently occurs before meals, and is partially relieved by food, antacids, or H2 blockers. Dysmotility-like symptoms consist of discomfort rather than pain, along with early satiety, postprandial fullness, nausea, vomiting, bloating, and symptoms that are worsened by food. Reflux-like symptoms consist of heartburn or acid regurgitation. However, symptoms often overlap.
Alternating constipation and diarrhea with dyspepsia suggests irritable bowel syndrome or excessive use of OTC laxatives or antidiarrheals.
Patients in whom symptoms suggest acute coronary ischemia, particularly those with risk factors, should be sent to the emergency department for urgent evaluation, including ECG and serum cardiac markers.
For patients with chronic, nonspecific symptoms, routine tests include CBC (to exclude anemia caused by GI blood loss) and routine blood chemistries. If results are abnormal, additional tests (eg, imaging studies, endoscopy) should be considered. Because of the risk of cancer, patients > 55 and those with new-onset red flag findings should undergo upper GI endoscopy. For patients < 55 with no red flag findings, some authorities recommend empiric therapy for 2 to 4 wk with antisecretory agents followed by endoscopy in treatment failures. Others recommend screening for H. pylori infection with a C14-urea breath test or stool assay (see Helicobacter pylori Infection : Noninvasive tests). However, caution is required in using H. pylori or any other nonspecific findings to explain symptoms.
Esophageal manometry and pH studies are indicated if reflux symptoms persist after upper GI endoscopy and a 2- to 4-wk trial with a PPI.
Specific conditions are treated. Patients without identifiable conditions are observed over time and reassured. Symptoms are treated with PPIs, H2 blockers, or a cytoprotective agent (see Table: Some Oral Drugs for Dyspepsia). Prokinetic drugs (eg, metoclopramide, erythromycin) given as a liquid suspension also may be tried in patients with dysmotility-like dyspepsia. However, there is no clear evidence that matching the drug class to the specific symptoms (eg, reflux vs dysmotility) makes a difference. Misoprostol and anticholinergics are not effective in functional dyspepsia. Drugs that alter sensory perception (eg, tricyclic antidepressants) may be helpful.
Some Oral Drugs for Dyspepsia
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