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Minhhuyen Nguyen

, MD, Fox Chase Cancer Center, Temple University

Last review/revision Mar 2021 | Modified Sep 2022
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An insulinoma is a rare pancreatic beta-cell tumor that hypersecretes insulin. The main symptom is fasting hypoglycemia. Diagnosis is by a 48- or 72-hour fast with measurement of glucose and insulin levels, followed by endoscopic ultrasound. Treatment is surgery when possible. Drugs that block insulin secretion (eg, diazoxide, octreotide, calcium channel blockers, beta-blockers, phenytoin) are used for patients not responding to surgery.

Insulinomas are a type of pancreatic endocrine tumor that arises from islet cells. Of all insulinomas, 80% are single and may be curatively resected if identified. Only 10% of insulinomas are malignant. Insulinoma occurs in 1/250,000 at a median age of 50 years, except in multiple endocrine neoplasia Multiple Endocrine Neoplasia, Type 1 (MEN 1) Multiple endocrine neoplasia, type 1 (MEN 1) is a hereditary syndrome characterized by hyperplasia or sometimes adenomas of the parathyroid glands, pancreatic islet cell tumors (also known as... read more (MEN) type 1 (about 10% of insulinomas), when it occurs in the 20s. Insulinomas associated with MEN 1 are more likely to be multiple.

Surreptitious administration of exogenous insulin can cause episodic hypoglycemia mimicking insulinoma.

Symptoms and Signs of Insulinoma

Hypoglycemia secondary to an insulinoma occurs during fasting. Symptoms of hypoglycemia due to insulinoma are insidious and may mimic various psychiatric and neurologic disorders. Central nervous system disturbances include headache, confusion, visual disturbances, motor weakness, palsy, ataxia, marked personality changes, and possible progression to loss of consciousness, seizures, and coma.

Symptoms of sympathetic stimulation (faintness, weakness, tremulousness, palpitation, sweating, hunger, and nervousness) are often present.

Diagnosis of Insulinoma

  • Insulin level

  • Sometimes C-peptide or proinsulin levels

  • Endoscopic ultrasound

Plasma glucose should be measured during symptoms while fasting. If hypoglycemia is present during symptoms (glucose < 55 mg/dL [3.0 mmol/L]) or without symptoms (glucose < 40 mg/dL [2.2 mmol/L]), an insulin level should be measured on a simultaneous sample. Hyperinsulinemia of > 6 mcU/mL (42 pmol/L) suggests an insulin-mediated cause, as does a serum insulin to plasma glucose ratio > 0.3 (mcU/mL)/(mg/dL) (38.2 when using SI units [pmol/L]/[mmol/L]).

Insulin is secreted as proinsulin, consisting of an alpha chain and beta chain connected by a C peptide. Because pharmaceutical insulin consists only of the beta chain, surreptitious insulin administration can be detected by measuring C-peptide and proinsulin levels. In patients with insulinoma, C peptide is 0.6 ng/mL (0.2 nmol/L) and proinsulin is 5 pmol/L. These levels are normal or low in patients with surreptitious insulin administration.

Because many patients have no symptoms (and hence no hypoglycemia) at the time of evaluation, diagnosis of insulinoma requires admission to the hospital for a 48- or 72-hour fast. Nearly all (98%) patients with insulinoma develop symptoms within 48 hours of fasting; 70 to 80% within 24 hours. Hypoglycemia as the cause of the symptoms is established by the Whipple triad:

  • Symptoms occur during the fast.

  • Symptoms occur in the presence of hypoglycemia.

  • Ingestion of carbohydrates relieves the symptoms.

Hormone levels are obtained as described above when the patient is having symptoms.

If the Whipple triad is not observed after prolonged fasting and the plasma glucose after an overnight fast is > 50 mg/dL (> 2.8 mmol/L), a C-peptide suppression test can be done. During insulin infusion (0.1 U/kg/hour), patients with insulinoma fail to suppress C peptide to normal levels ( 1.2 ng/mL [ 0.40 nmol/L]).

Endoscopic ultrasonography has > 90% sensitivity and helps localize the tumor. Positron emission tomography (PET) also may be used. CT has not proved useful, and arteriography or selective portal and splenic vein catheterization is generally unnecessary.

Treatment of Insulinoma

  • Surgical resection

  • Diazoxide or sometimes octreotide for hypoglycemia

  • Chemotherapy

Overall surgical cure rates approach 90%. A small, single insulinoma at or near the surface of the pancreas can usually be enucleated surgically. If a single large or deep adenoma is within the pancreatic body or tail, if there are multiple lesions of the body or tail (or both), or if no insulinoma is found (an unusual circumstance), a distal, subtotal pancreatectomy is done. In < 1% of cases, the insulinoma is ectopically located in peripancreatic sites of the duodenal wall or periduodenal area and can be found only by diligent search during surgery. Pancreatoduodenectomy (Whipple procedure) is done for resectable malignant insulinomas of the proximal pancreas. Total pancreatectomy is done if a previous subtotal pancreatectomy proves inadequate.

If hypoglycemia continues, diazoxide starting at 1.5 mg/kg orally 2 times a day with a natriuretic can be used. Doses can be increased up to 4 mg/kg. A somatostatin analog, octreotide (100 to 500 mcg subcutaneously twice a day to 3 times a day), is variably effective and should be considered for patients with continuing hypoglycemia refractory to diazoxide. Patients who respond may be converted to a long-acting octreotide formulation given as 20 to 30 mg IM once a month. Patients using octreotide may also need to take supplemental pancreatic enzymes because octreotide suppresses pancreatic enzyme secretion. Other drugs that have modest and variable effect on insulin secretion include verapamil, diltiazem, and phenytoin.

If symptoms are not controlled, chemotherapy may be tried, but response is limited. Streptozotocin has a 30 to 40% response rate and, when combined with 5-fluorouracil, a 60% response rate lasting up to 2 years. Other agents include doxorubicin, chlorozotocin, and interferon. Newer chemotherapies under investigation for insulinoma include temozolomide-based regimens, everolimus, or sunitinib.

Key Points

  • Only about 10% of insulinomas are malignant, but all cause fasting hypoglycemia.

  • Glucose and insulin levels are measured during symptoms (either spontaneous or induced by fasting during hospitalization).

  • Endoscopic ultrasonography has > 90% sensitivity for locating the tumor; positron emission tomography (PET) also may be used, but CT is not useful.

  • About 90% of insulinomas can be resected surgically.

  • Control symptoms of hypoglycemia with diazoxide or sometimes octreotide.

Drugs Mentioned In This Article

Drug Name Select Trade
Afrezza, Exubera
Hyperstat, Proglycem
Bynfezia, Mycapssa, Sandostatin, Sandostatin LAR
Dilantin, Dilantin Infatabs, Dilantin-125, Phenytek
Calan, Calan SR, Covera-HS, Isoptin, Isoptin SR, Verelan, Verelan PM
Cardizem, Cardizem CD, Cardizem LA, Cardizem SR, Cartia XT , Dilacor XR, Dilt-CD , Diltia XT, Diltzac, Matzim LA, Taztia XT, TIADYLT ER, Tiamate, Tiazac
Adrucil, Carac, Efudex, Fluoroplex, Tolak
Adriamycin, Adriamycin PFS, Adriamycin RDF, Rubex
Afinitor , Afinitor DISPERZ, Zortress
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