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Overview of Renal Replacement Therapy


L. Aimee Hechanova

, MD, Texas Tech University Health Sciences Center, El Paso

Reviewed/Revised Sep 2022
Topic Resources

RRT does not correct the endocrine abnormalities (decreased erythropoietin and 1,25-dihydroxyvitamin D3 production Vitamin D Deficiency and Dependency Inadequate exposure to sunlight predisposes to vitamin D deficiency. Deficiency impairs bone mineralization, causing rickets in children and osteomalacia in adults and possibly contributing... read more ) of renal failure. During dialysis, serum solute (eg, sodium, chloride, potassium, bicarbonate, calcium, magnesium, phosphate, urea, creatinine, uric acid) diffuses passively between fluid compartments down a concentration gradient (diffusive transport). During filtration, serum water passes between compartments down a hydrostatic pressure gradient, dragging solute with it (convective transport). The two processes are often used in combination (hemodiafiltration). Hemoperfusion is a rarely used technique that removes toxins by flowing blood over a bed of adsorbent material (usually a resin compound or charcoal).

Dialysis and filtration can be done intermittently or continuously. Continuous therapy is used almost exclusively for acute kidney injury Acute Kidney Injury (AKI) Acute kidney injury is a rapid decrease in renal function over days to weeks, causing an accumulation of nitrogenous products in the blood (azotemia) with or without reduction in amount of urine... read more . Continuous therapy is sometimes better tolerated than intermittent therapy in unstable patients because solute and water are removed more slowly. All forms of RRT except peritoneal dialysis require vascular access; continuous techniques require a direct arteriovenous or venovenous circuit.

The choice of technique depends on multiple factors, including the primary need (eg, solute or water removal or both), underlying indication (eg, acute or chronic kidney failure, poisoning), vascular access, hemodynamic stability, availability, local expertise, and patient preference and capability (eg, for home dialysis). The table Indications and Contraindications to Common Renal Replacement Therapies Indications and Contraindications to Common Renal Replacement Therapies Indications and Contraindications to Common Renal Replacement Therapies lists indications and contraindications for the common forms of RRT.


Care of patients requiring long-term RRT Medical Aspects of Long-Term Renal Replacement Therapy All patients undergoing long-term renal replacement therapy (RRT) develop accompanying metabolic and other disorders. These disorders require appropriate attention and adjunctive treatment.... read more Medical Aspects of Long-Term Renal Replacement Therapy ideally involves a nephrologist, a psychiatrist, a social worker, a renal dietitian, dialysis nurses, a vascular surgeon (or other surgeon skilled in peritoneal dialysis catheter placement), and the transplant surgical team. Patient assessment should begin when end-stage renal failure Chronic Kidney Disease Chronic kidney disease (CKD) is long-standing, progressive deterioration of renal function. Symptoms develop slowly and in advanced stages include anorexia, nausea, vomiting, stomatitis, dysgeusia... read more Chronic Kidney Disease is anticipated but before RRT is needed, so that care can be coordinated and patients can be educated about their options, evaluated for resources and needs, and have vascular access created.

Psychosocial evaluation is important because RRT makes patients socially and emotionally vulnerable. It interrupts routine work, school, and leisure activities; creates anger, frustration, tension, and guilt surrounding dependency; and alters body image because of reduced physical energy, loss of or change in sexual function, changed appearance due to access surgery, dialysis catheter placement, needle marks, bone disease, or other physical deterioration. Some patients react to these feelings by nonadherence or by being uncooperative with the treatment team.

Personality traits that improve prognosis for successful long-term adjustment include adaptability, independence, self-control, tolerance for frustration, and optimism. Emotional stability, family encouragement, consistent treatment team support, and patient and family participation in decision-making are also important. Programs that encourage patient independence and maximal resumption of former life interests are more successful in decreasing psychosocial problems.

Drugs Mentioned In This Article

Drug Name Select Trade
Aluvea , BP-50% Urea , BP-K50, Carmol, CEM-Urea, Cerovel, DermacinRx Urea, Epimide-50, Gord Urea, Gordons Urea, Hydro 35 , Hydro 40, Kerafoam, Kerafoam 42, Keralac, Keralac Nailstik, Keratol, Keratol Plus, Kerol, Kerol AD, Kerol ZX, Latrix, Mectalyte, Nutraplus, RE Urea 40, RE Urea 50 , Rea Lo, Remeven, RE-U40, RYNODERM , U40, U-Kera, Ultra Mide 25, Ultralytic-2, Umecta, Umecta Nail Film, URALISS, Uramaxin , Uramaxin GT, Urea, Ureacin-10, Ureacin-20, Urealac , Ureaphil, Uredeb, URE-K , Uremez-40, Ure-Na, Uresol, Utopic, Vanamide, Xurea, X-VIATE
Actidose With Sorbitol , Actidose-Aqua, Charcoal Plus DS , CharcoCaps Anti-Gas, EZ Char , Kerr INSTA-CHAR
NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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