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Placenta Accreta

(Placenta Accreta Spectrum)


Julie S. Moldenhauer

, MD, Children's Hospital of Philadelphia

Reviewed/Revised Jul 2021 | Modified Sep 2022

Placenta accreta is an abnormally adherent placenta, resulting in delayed delivery of the placenta. Placental function is normal, but trophoblastic invasion extends beyond the normal boundary (called Nitabuch layer). In such cases, manual removal of the placenta, unless scrupulously done, results in massive postpartum hemorrhage. Prenatal diagnosis is by ultrasonography. Treatment is usually with scheduled cesarean hysterectomy.

In placenta accreta, the placental villi are not contained by uterine decidual cells, as occurs normally, but extend to the myometrium.

Related abnormalities include

  • Placenta increta (invasion of chorionic villi into the myometrium)

  • Placenta percreta (penetration of chorionic villi into or through the uterine serosa)

All three abnormalities cause similar problems.


The main risk factor for placenta accreta is

  • Prior uterine surgery

In the US, placenta accreta most commonly occurs in women who

Incidence of placenta accreta has been increasing; it occurred in about

In women who have placenta previa, the risk of placenta accreta increases from about 10% if they have had one cesarean delivery to > 60% if they have had > 4 cesarean deliveries. For women without placenta previa, having had a previous cesarean delivery increases risk very slightly (< 1% for up to 4 cesarean deliveries).

Other risk factors include the following:

  • Maternal age > 35

  • Multiparity (risk increases as parity increases)

  • Submucosal fibroids

  • Prior uterine surgery, including myomectomy

  • Endometrial lesions such as Asherman syndrome

Etiology reference

  • 1. Mogos MF, Salemi JL, Ashley M, et al: Recent trends in placenta accreta in the United States and its impact on maternal–fetal morbidity and healthcare-associated costs, 1998–2011. J Matern Fetal Neonatal Med 29 (7):1077–1082, 2016, 2016. doi: 10.3109/14767058.2015.1034103

Symptoms and Signs

Usually, vaginal bleeding is profuse during manual separation of the placenta after delivery of the fetus. However, bleeding may be minimal or absent, but the placenta may not be delivered within 30 minutes after delivery of the fetus.


  • Ultrasonography for women at risk

Thorough evaluation of the uteroplacental interface by ultrasonography (transvaginal or transabdominal) is warranted in women at risk; it can be done periodically, beginning at 20 to 24 weeks gestation. If B-mode (gray-scale) ultrasonography is inconclusive, MRI or Doppler flow studies may help.

During delivery, placenta accreta is suspected if

  • The placenta has not been delivered within 30 minutes of the infant's delivery.

  • Attempts at manual removal cannot create a plane of separation.

  • Placental traction causes large-volume hemorrhage.

When placenta accreta is suspected, laparotomy with preparation for large-volume hemorrhage is required.


  • Scheduled cesarean hysterectomy

If placenta accreta is suspected, clinicians should consider referring the woman to a center with expertise in managing this disorder.

Preparation for delivery is best. Usually, unless the woman objects, cesarean hysterectomy is done at 34 weeks; this approach tends to result in the best balance of maternal and fetal outcomes.

If cesarean hysterectomy is done (preferably by an experienced pelvic surgeon), a fundal incision followed by immediate clamping of the cord after delivery can help minimize blood loss. The placenta is left in situ while hysterectomy is done. Balloon occlusion of the aorta or internal iliac vessels may be done preoperatively but requires a skilled angiographer and may cause serious thromboembolic complications.

Rarely (eg, when placenta accreta is focal, fundal, or posterior), clinicians can attempt to save the uterus, but only if acute hemorrhage is absent. For example, the uterus can be left in place, and a high dose of methotrexate can be given to dissolve the placenta; this procedure is done only in certain centers. Uterine artery embolization, arterial ligation, and balloon tamponade are also sometimes used.

Key Points

  • In the US, placenta accreta is becoming increasingly common, occurring most often in women who have placenta previa and have had a cesarean delivery in a previous pregnancy.

  • Consider using periodic ultrasonography to screen women who are > 35 years of age or are multiparous (particularly if placenta previa developed previously or they have had a prior cesarean delivery), who have submucosal fibroids or endometrial lesions, or who have had prior uterine surgery.

  • Suspect placenta accreta if the placenta has not been delivered within 30 minutes of the infant's delivery, if attempts at manual removal cannot create a plane of separation, or if placental traction causes large-volume hemorrhage.

  • If placenta accreta is diagnosed, do cesarean hysterectomy at 34 weeks, unless the woman objects.

  • Consider referral to a center with expertise in managing placenta accreta.

Drugs Mentioned In This Article

Drug Name Select Trade
Otrexup, Rasuvo, RediTrex, Rheumatrex, Trexall, Xatmep
NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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