Merck Manual

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Phyllodes Tumor

(Cystosarcoma Phyllodes)

By

Lydia Choi

, MD, Karmanos Cancer Center

Last full review/revision Mar 2022
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Phyllodes tumor is a nonepithelial breast tumor that may be benign or malignant.

Phyllodes tumors are frequently large (4 to 5 cm) at diagnosis. About 10 to 25% are malignant ( 1 Reference Phyllodes tumor is a nonepithelial breast tumor that may be benign or malignant. Phyllodes tumors are frequently large (4 to 5 cm) at diagnosis. About 10 to 25% are malignant ( 1), accounting... read more ), accounting for < 1% of breast cancers. Between 20% and 35% of these tumors recur locally, and distant metastases occur in 10 to 20% of patients.

Usual treatment of a phyllodes tumor is wide excision, but a mastectomy may be more appropriate if the mass is large or histology suggests cancer. Radiation therapy may be recommended in some cases.

Prognosis is good unless metastases (usually pulmonary) are present.

Reference

  • 1. Rosenberger LH, Thomas SM, Nimbkar SN, et al: Contemporary multi-institutional cohort of 550 cases of phyllodes tumors (2007-2017) demonstrates a need for more individualized margin guidelines. J Clin Oncol 2021 39 (3):178–189. doi: 10.1200/JCO.20.02647 Epub 2020 Dec 10.

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