Inflammatory Vaginitis

(Desquamative Inflammatory Vaginitis)

ByOluwatosin Goje, MD, MSCR, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University
Reviewed/Revised Mar 2023
View Patient Education

(See also Overview of Vaginitis.)

In patients with inflammatory vaginitis, vaginal epithelial cells slough superficially, and streptococci overgrow.

Inflammatory vaginitis occurs and recurs most commonly in patients who become hypoestrogenic due to menopause or primary ovarian insufficiency (premature ovarian failure—eg, due to autoimmune disease, oophorectomy, pelvic radiation, or chemotherapy). The etiology may be autoimmune.

Symptoms and Signs of Inflammatory Vaginitis

Purulent vaginal discharge, dyspareunia, dysuria, and vaginal irritation are common. Vaginal pruritus and erythema may occur. Burning, pain, or mild bleeding occurs less often. Vaginal tissue may appear thin and dry. Vaginitis may recur.

Patients who are postmenopausal or those with premature ovarian insufficiency may also have signs and symptoms of genitourinary syndrome of menopause (eg, vulvovaginal atrophy, urinary urgency, dysuria).

Diagnosis of Inflammatory Vaginitis

  • Vaginal pH and wet mount

Symptoms of inflammatory vaginitis overlap with other forms of vaginitis, and a general evaluation (eg, vaginal fluid pH measurement, microscopy, whiff test) should be performed.

Inflammatory vaginitis is diagnosed if

  • Vaginal fluid pH is > 6.

  • Whiff test is negative.

  • Microscopy shows predominantly white blood cells and parabasal cells.

The pelvic examination should include evaluation for characteristic findings of vulvovaginal atrophy (eg, labia minora resorption or fusion, tissue fragility, pallor, loss of vaginal rugae).

Treatment of Inflammatory Vaginitis

Genital atrophy, if present, can be treated with topical estrogen such as the following:

Topical estrogen therapy is usually preferred for genitourinary syndrome of menopause, because it is more effective for this indication and has lower risk of adverse effects than systemic menopausal hormone therapy.

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