Merck Manual

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James Peter Adam Hamilton

, MD, Johns Hopkins University School of Medicine

Reviewed/Revised Sep 2022
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Hemosiderosis is focal deposition of iron that does not typically cause tissue damage.

Focal hemosiderosis can result from hemorrhage within an organ. Iron liberated from extravasated red blood cells is deposited within that organ, and significant hemosiderin deposits may eventually develop. Iron loss due to hemorrhage can still occur and cause iron deficiency anemia Iron Deficiency Anemia Iron deficiency is the most common cause of anemia and usually results from blood loss; malabsorption, such as with celiac disease, is a much less common cause. Symptoms are usually nonspecific... read more Iron Deficiency Anemia because iron stored in nonhematopoietic tissues cannot be reused.

Another common site of accumulation is the kidneys, where hemosiderosis can result from extensive intravascular hemolysis Overview of Hemolytic Anemia At the end of their normal life span (about 120 days), red blood cells (RBCs) are removed from the circulation. Hemolysis is defined as premature destruction and hence a shortened RBC life span... read more Overview of Hemolytic Anemia . Free hemoglobin is filtered at the glomerulus, resulting in iron deposition in the kidneys. The renal parenchyma is not damaged, but severe hemosiderinuria may result in iron deficiency.

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