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Hematopoietic Cell Transplantation

By

Robert Peter Gale

, MD, PhD, Imperial College London

Last full review/revision Sep 2020| Content last modified Sep 2020
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Hematopoietic cell transplants Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers (leukemias, lymphomas, myeloma) and other hematologic disorders... read more using cells from bone marrow, blood, or less often, umbilical cord blood cells are given after high- or moderate-dose chemotherapy and/or radiation therapy. Donors can be the person with cancer (an autotransplant) or an HLA-matched related or unrelated person (an allotransplant—see also Overview of Cancer Therapy Overview of Cancer Therapy Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. The major modalities of therapy are Surgery (for local and local-regional disease) Radiation... read more ). Typically, such transplants are reserved for patients with a high risk that conventional therapies will fail or in whom initial therapy has failed.

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