Merck Manual

Please confirm that you are a health care professional

Loading

Nitrofurantoin

By

Brian J. Werth

, PharmD, University of Washington School of Pharmacy

Last full review/revision May 2020| Content last modified May 2020
Click here for Patient Education

Nitrofurantoin is a bactericidal antibiotic; the exact mechanism is unknown.

Nitrofurantoin is available only for oral use.

Pharmacokinetics

After a single dose of nitrofurantoin, serum drug levels are very low, but urine drug levels are therapeutic.

Indications

Nitrofurantoin is active against common uropathogens, such as

E. faecium, including vancomycin-resistant strains, and Klebsiella and Enterobacter species are less susceptible. Most strains of Proteus, Providencia, Morganella, Serratia, Acinetobacter, and Pseudomonas species are resistant. There is no cross-resistance with other antibiotic classes.

Nitrofurantoin is used only for

  • Treatment or prophylaxis of uncomplicated lower urinary tract infection (cystitis)

In women with recurrent urinary tract infections, it may decrease the number of episodes.

Contraindications

Contraindications to nitrofurantoin use include

  • Previous allergic reaction to it

  • Renal insufficiency (creatinine clearance < 60 L/minute)

  • Age < 1 month

  • Pregnancy at term (38 to 42 weeks gestation), during labor and delivery, or when the onset of labor is imminent.

Use During Pregnancy and Breastfeeding

Animal reproduction studies with nitrofurantoin have not shown risk to the fetus. No adequate and well-controlled studies have been done in pregnant women, but nitrofurantoin is generally considered to be safe during all 3 trimesters of pregnancy. However, nitrofurantoin is contraindicated at term and during labor or delivery because it interferes with immature enzyme systems in red blood cells of neonates, damaging the cells, and may result in hemolytic anemia.

Nitrofurantoin enters breast milk and should be avoided if possible during the first month of breastfeeding to reduce the risk of hemolytic anemia, especially in infants with hyperbilirubinemia.

Adverse Effects

Adverse effects of nitrofurantoin include

  • Gastrointestinal disturbances

  • Pulmonary toxicity

  • Peripheral neuropathy

  • Hemolytic anemia

  • Hepatic toxicity

Common adverse effects are nausea and vomiting, which are less likely with the macrocrystalline form. Fever, rash, acute hypersensitivity pneumonitis (accompanied by fever and eosinophilia), and chronic progressive pulmonary interstitial fibrosis may occur. Paresthesias may result and may be followed by a severe ascending motor and sensory polyneuropathy if the drug is continued, especially in patients with renal failure.

Leukopenia and hepatic toxicity (acute cholestatic or chronic active hepatitis) have been reported, and hemolytic anemia can occur in patients with G6PD deficiency and in infants < 1 month of age.

Chronic pulmonary and hepatic reactions occur when the drug is used for > 6 months.

Drugs Mentioned In This Article

Drug Name Select Trade
FURADANTIN, MACROBID, MACRODANTIN
VANCOCIN
Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Also of Interest

Videos

View All
Overview of Lyme Disease
Video
Overview of Lyme Disease
3D Models
View All
SARS-CoV-2
3D Model
SARS-CoV-2

SOCIAL MEDIA

TOP