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Some HLA-Based Risk Factors for Drug Hypersensitivity

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Medication	Ethnicity	HLA Haplotype	Hypersensitivity Reaction
AbacavirAbacavir	European ancestry	HLA-B*5701	Abacavir hypersensitivity (usually fever, rash, and GI and respiratory symptoms)Abacavir hypersensitivity (usually fever, rash, and GI and respiratory symptoms)
AllopurinolAllopurinol	Asian ancestry, African ancestry Less often, European ancestry	HLA-B*5801	SJS/TEN; DRESS
CarbamazepineCarbamazepine	European ancestry, Japanese ancestry	HLA-A*3101	SJS/TEN
CarbamazepineCarbamazepine	Asian ancestry	HLA-B*1502	SJS/TEN; DRESS
DapsoneDapsone	Mainland Chinese ancestry	HLA-B*1301	DRESS
FosphenytoinFosphenytoin PhenytoinPhenytoin	Asian ancestry	HLA-B*1502	SJS/TEN
LamotrigineLamotrigine	Asian ancestry	HLA-B*1502	SJS/TEN
DRESS = drug rash with eosinophilia and systemic symptoms; GI = gastrointestinal; HLA = human leukocyte antigen; SJS/TEN = Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).