Merck Manual

Please confirm that you are a health care professional

honeypot link
Selected Conditions Associated With Clostridial Infections

Selected Conditions Associated With Clostridial Infections

Condition

Agent

Toxin

Soft-tissue infection

C. perfringens, others

Alpha-toxin (phospholipase C), theta-toxin, others

C. septicum

Alpha-toxin, beta-toxin, hyaluronidase gamma-toxin, septicolysin delta-toxin

Enteric diseases

C. perfringens type A

Enterotoxin

C. perfringens type C

Beta-toxin

Clostridioides difficile (formerly Clostridium difficile)

Toxin A or B or C. difficile binary toxin (CDT)

C. septicum, others

Unknown, possibly beta-toxin

C. septicum

C. perfringens, C. ramosum, many others

Beta-toxin*

Neurologic syndromes

C. tetani

Tetanospasmin

C. botulinum

Botulinal toxins A–G and F/A Hybrid

* Beta-toxin is produced by C. perfringens type C, but most of these infections are caused by C. perfringens type A, which does not produce beta-toxin.