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Variant Expressions of Multiple Myeloma

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Form	Characteristics
Extramedullary plasmacytoma	Plasmacytomas that occur outside of the bone marrow
Solitary plasmacytoma of bone	Single bone plasmacytomas, which usually produce no M-protein
Osteosclerotic myeloma (POEMS syndrome)	Polyneuropathy (chronic inflammatory polyneuropathy) Organomegaly (hepatomegaly, splenomegaly, or lymphadenopathy) Endocrinopathy (eg, gynecomastia, testicular atrophy) M-protein Skin changes (eg, hyperpigmentation, excess hair)
Nonsecretory myeloma	Absence of M-protein in serum and urine Absence of elevated serum free light chains