Merck Manual

Please confirm that you are a health care professional

honeypot link

Air Filters Shown to Improve Breathing in Children With Asthma

05/26/20 By
HealthDay News

TUESDAY, May 26, 2020 (HealthDay News) -- Daily use of a fine particulate matter air filtration device can significantly improve airway mechanics and reduce airway resistance in children with asthma, according to a study recently published in JAMA Pediatrics.

Xiaoxing Cui, Ph.D., of the Nicholas School of the Environment at Duke University in Durham, North Carolina, and colleagues performed a double-blind study of 43 children with mild-to-moderate asthma (ages ranging from 5 to 13 years) to test the efficacy of daily use of a fine particle (generalized particulate matter 2.5 µm in size [PM2.5]) filter device. The authors initiated random placement of a working PM2.5 filtration device and a placebo filtration device within the children's bedrooms for two weeks, incorporating a two week washout interval period.

The researchers found that while using the PM2.5 filtration device, the concentrations of PM2.5 within the bedrooms were a mean (SD) of 63.4 percent (35.9 percent) lower than when the placebo filter was used. The use of a true filter also incrementally improved airway mechanics, shown in peak expiratory flow (1.6 percent) and fractional exhaled nitric oxide (a 27.6 percent reduction). Additionally, the children exhibited a reduction in total airway resistance of 24.4 percent, a reduction of 43.5 percent in small airway resistance, an reduction of 22.2 percent in resonant frequency, and an increase of 73.1 percent in airway reactance.

"These observations support a future clinical trial to assess the efficacy and effectiveness of indoor air filtration in improving small airway pathophysiology that plays a vital role in asthma," the authors write.

Abstract/Full Text (subscription or payments may be required)

Test your knowledge
Overview of Stroke
A 63-year-old woman is brought to the emergency department because she has had loss of vision in her right eye and memory loss for the past hour. On physical examination, the pupil on the right is enlarged and the patient is unable to move the eye inward or up. Based on this information, this patient has most likely sustained a stroke to which of the following arteries?