Merck Manual

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Progressive Rubella Panencephalitis


Brenda L. Tesini

, MD, University of Rochester School of Medicine and Dentistry

Last full review/revision Aug 2019| Content last modified Aug 2019
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Progressive rubella panencephalitis is a neurologic disorder occurring in children with congenital rubella. It is presumably due to persistence or reactivation of rubella virus infection.

Most viruses that infect humans can affect both adults and children and are discussed elsewhere in THE MANUAL. Viruses with specific effects on neonates are discussed in Infections in Neonates. This chapter covers viral infections that are typically acquired during childhood (although many may also affect adults).

Some children with congenital rubella syndrome (eg, with deafness, cataracts, microcephaly, and intellectual disability) develop neurologic deficits in early adolescence.


  • Cerebrospinal fluid (CSF) examination and serologic testing

  • CT

  • Sometimes brain biopsy

The diagnosis of progressive rubella panencephalitis is considered when a child with congenital rubella develops progressive spasticity, ataxia, mental deterioration, and seizures. Testing involves at least CSF examination and serologic testing. CSF total protein and globulin and rubella antibody titers in CSF and serum are elevated.

CT may show ventricular enlargement due to cerebellar atrophy and white matter disease.

Brain biopsy may be necessary to exclude other causes of encephalitis or encephalopathy. Rubella virus usually cannot be recovered by viral culture or immunohistologic testing.


No specific progressive rubella panencephalitis treatment exists. Symptoms (eg, seizures, muscle spasticity, weakness) are managed as appropriate.

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