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Coal Workers’ Pneumoconiosis

(Anthracosis; Black Lung Disease; Coal Miner’s Pneumoconiosis)

By

Abigail R. Lara

, MD, University of Colorado

Last full review/revision May 2020| Content last modified May 2020
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Topic Resources

Coal workers’ pneumoconiosis is caused by inhalation of coal dust. Deposition of dust produces dust-laden macrophages around bronchioles (coal macules), occasionally causing focal bronchiolar emphysema. Coal workers' pneumoconiosis usually causes no symptoms but can progress to progressive massive fibrosis with impaired lung function. Diagnosis is based on history and chest x-ray findings. Treatment is generally supportive.

Etiology of Coal Workers’ Pneumoconiosis

Coal workers' pneumoconiosis is caused by chronic inhalation of dust from high-carbon coal (anthracite and bituminous) and rarely graphite, typically over 20 years. Inhalation of silica contained in coal may also contribute to clinical disease.

Pathophysiology of Coal Workers’ Pneumoconiosis

Alveolar macrophages engulf the dust, release cytokines that stimulate inflammation, and collect in lung interstitium around bronchioles and alveoli (coal macules). Coal nodules develop as collagen accumulates, and focal emphysema develops as bronchiole walls weaken and dilate. Fibrosis can occur but is usually limited to areas adjacent to coal macules. Distortion of lung architecture, airflow obstruction, and functional impairment are usually mild but can be highly destructive in some patients.

Two forms of coal workers' pneumoconiosis are described:

  • Simple, with individual coal macules

  • Complicated, with coalescence of macules and progressive massive fibrosis

Patients with simple coal workers' pneumoconiosis develop progressive massive fibrosis at a rate of about 1 to 2% /year. Recently, rapid progression of coal workers' pneumoconiosis to progressive massive fibrosis has been recognized in young miners, especially in the eastern US compared to the rest of the United States (1 Key Points Coal workers’ pneumoconiosis is caused by inhalation of coal dust. Deposition of dust produces dust-laden macrophages around bronchioles (coal macules), occasionally causing focal bronchiolar... read more Key Points ).

In progressive massive fibrosis, nodules coalesce to form black, rubbery parenchymal masses usually in the upper posterior lung fields. The masses may encroach on and destroy vascular supply and airways or may cavitate. Progressive massive fibrosis can develop and progress even after exposure to coal dust has ceased. Despite the similarity of coal-induced progressive massive fibrosis and conglomerate silicosis, the development of progressive massive fibrosis in coal workers is unrelated to the silica content of the coal. However, exposure to silica in coal is required for progression from coal workers' pneumoconiosis to progressive massive fibrosis, and exposure to graphite alone can cause coal workers' pneumoconiosis but not progression to progressive massive fibrosis.

A small percentage of patients with coal workers' pneumoconiosis develop diffuse pulmonary fibrosis.

Complications

An association between coal workers' pneumoconiosis and features of rheumatoid arthritis Rheumatoid Arthritis (RA) Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily involves the joints. RA causes damage mediated by cytokines, chemokines, and metalloproteases. Characteristically... read more Rheumatoid Arthritis (RA) is well-described. It is unclear whether coal worker's pneumoconiosis predisposes miners to developing rheumatoid arthritis, whether rheumatoid arthritis takes on a unique form in patients with coal workers' pneumoconiosis, or whether rheumatoid arthritis alters the response of miners to coal dust. Multiple rounded nodules in the lung appearing over a relatively short time (Caplan syndrome) represent an immunopathologic response related to rheumatoid diathesis. Histologically, they resemble rheumatoid nodules but have a peripheral region of more acute inflammation.

Pathophysiology reference

  • 1. Almberg KS, Halldin CN, Blackley DJ, et al: Progressive massive fibrosis resurgence identified in U.S. coal miners filing for black lung benefits, 1970-2016. Ann Am Thorac Soc 15(12):1420–1426, 2018. doi: 10.1513/AnnalsATS.201804-261OC

Symptoms and Signs of Coal Workers’ Pneumoconiosis

Diagnosis of Coal Workers’ Pneumoconiosis

  • History of exposure to coal dust

  • Chest CT or chest x-ray

Diagnosis of coal workers’ pneumoconiosis is based on a history of exposure to coal dust and chest x-ray or chest CT appearance.

In patients with coal workers' pneumoconiosis, chest x-ray or CT reveals diffuse, small, rounded opacities or nodules. The finding of at least one opacity > 10 mm suggests progressive massive fibrosis. The specificity of the chest x-ray for progressive massive fibrosis is low because up to one third of the lesions identified as being progressive massive fibrosis turn out to be cancers, scars, or other disorders. Chest CT is more sensitive and specific than chest x-ray for detecting coalescing nodules, early progressive massive fibrosis, and cavitation.

Diffuse pulmonary fibrosis is characterized by lower lobe predominant reticular opacities. Honeycomb changes have also been reported.

Pulmonary function tests Overview of Tests of Pulmonary Function Pulmonary function tests provide measures of airflow, lung volumes, gas exchange, response to bronchodilators, and respiratory muscle function. Basic pulmonary function tests available in the... read more are nondiagnostic but are useful for characterizing lung function in patients in whom obstructive, restrictive, or mixed defects may develop. Because abnormalities of gas exchange occur in some patients with extensive simple coal workers' pneumoconiosis and in those with complicated coal worker's pneumoconiosis, baseline and periodic measures of diffusing capacity for carbon monoxide (DLCO) and arterial blood gas levels at rest and during exercise are recommended.

Because patients with coal workers' pneumoconiosis often have had exposure to both silica dust and coal dust, surveillance for tuberculosis Tuberculosis (TB) Tuberculosis (TB) is a chronic, progressive mycobacterial infection, often with a period of latency following initial infection. TB most commonly affects the lungs. Symptoms include productive... read more Tuberculosis (TB) (TB) is usually done. Patients with coal workers' pneumoconiosis should have annual tuberculin skin testing. In those with positive test results, sputum culture and cytology, CT, and bronchoscopy may be needed to confirm TB.

Treatment of Coal Workers’ Pneumoconiosis

  • Sometimes supplemental oxygen and pulmonary rehabilitation

  • Restriction from further exposure

Treatment is rarely necessary in simple coal workers' pneumoconiosis, although smoking cessation Smoking Cessation Most smokers want to quit and have tried doing so with limited success. Effective interventions include cessation counseling and drug treatment, such as varenicline, bupropion, or a nicotine... read more and TB surveillance are recommended. Patients with pulmonary hypertension, hypoxemia, or both are given supplemental oxygen therapy.

Prevention of Coal Workers’ Pneumoconiosis

Preventive measures include eliminating exposure, stopping smoking, and giving pneumococcal and influenza vaccinations. Coal workers' pneumoconiosis can be prevented by suppressing coal dust at the coal face. Despite long-standing regulations, exposures continue to occur in the mining trade, resulting in increased rates of disease, including severe forms.

Respiratory masks provide only limited protection.

Key Points

  • Coal workers’ pneumoconiosis is caused by chronic inhalation of dust from high-carbon coal (anthracite and bituminous) and rarely graphite, typically over ≥ 20 years.

  • Most patients have simple coal workers' pneumoconiosis, with small, asymptomatic nodules seen on imaging.

  • Some patients with coal workers' pneumoconiosis develop progressive massive fibrosis, with deterioration of pulmonary function, dyspnea, and marked abnormalities on imaging studies.

  • Base the diagnosis on history of exposure as well as chest imaging.

  • Treat supportively, encourage smoking cessation, and restrict further exposure.

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