Pneumomediastinum

ByNajib M Rahman, BMBCh MA (oxon) DPhil, University of Oxford
Reviewed ByM. Patricia Rivera, MD, University of Rochester Medical Center
Reviewed/Revised Modified Jul 2025
v923118
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Pneumomediastinum is air in mediastinal interstices.

The main causes of pneumomediastinum are:

  • Alveolar rupture with dissection of air into the interstitium of the lung with translocation to the mediastinum

  • Esophageal perforation

  • Esophageal or bowel rupture with dissection of air from the neck or the abdomen into the mediastinum

Tension pneumomediastinum with compression of mediastinal structures is rare.

The primary symptom is substernal chest pain which can, on occasion, be severe.

Physical examination may show subcutaneous emphysema, usually in the suprasternal notch, along with a crunching or clicking noise synchronous with the heartbeat; this noise is best heard over the heart when the patient is in the left lateral decubitus position (Hamman sign).

The diagnosis is confirmed by chest radiograph, which shows air in the mediastinum.

The cause of pneumomediastinum must be identified to exclude esophageal perforation, which requires hospitalization and treatment.

Pearls & Pitfalls

  • Although pneumomediastinum may produce dramatic findings on examination and/or radiograph and may indicate a serious disorder, treatment of pneumomediastinum itself is usually unnecessary.

Treatment of Pneumomediastinum

  • Usually unnecessary

Treatment usually is not necessary, although tension pneumomediastinum with compression of mediastinal structures can be relieved with needle aspiration, leaving the needle open to the atmosphere as is performed with tension pneumothorax.

Hospital admission is required if pneumomediastinum is secondary to esophageal or bowel rupture but not necessarily if secondary to alveolar rupture.

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