Herpes Zoster Vaccine
For more information, see Zoster (Shingles) ACIP Vaccine Recommendations.
A severe allergic reaction (eg, anaphylaxis) to a vaccine component
Known severe primary or acquired immunodeficiency (eg, due to leukemia, lymphomas, solid tumors, tumors that affect bone marrow or the lymphatic system, AIDS, severe HIV infection, treatment with chemotherapy, or long-term use of immunosuppressants)
Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves)
Use of specific antiviral drugs: acyclovir, famciclovir, or valacyclovir (if possible, vaccination is postponed until 24 h after use of these drugs, and the drugs are not resumed for 14 days after vaccination)
The vaccine is given as a single 0.65-mL dose sc in the deltoid region of the upper arm.
Zoster vaccine should be given ≥ 14 days before immunosuppressive therapy is begun; some experts prefer waiting 1 mo after zoster vaccination to begin immunosuppressive therapy if possible.
This vaccine must be kept frozen between -50° C (-58° F) and -15° C (5° F) and must be reconstituted immediately after removal from the freezer.