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Paronychia is infection of the periungual tissues. Acute paronychia causes redness, warmth, and pain along the nail margin. Diagnosis is by inspection. Treatment is with antistaphylococcal antibiotics and drainage of any pus.
Paronychia is usually acute, but chronic cases occur (see Chronic Paronychia). In acute paronychia, the causative organisms are usually Staphylococcus aureus or streptococci and, less commonly, Pseudomonas or Proteus spp. Organisms enter through a break in the epidermis resulting from a hangnail, trauma to a nail fold, loss of the cuticle, or chronic irritation (eg, resulting from water and detergents). Biting or sucking the fingers can also predispose people to developing the infection. In toes, infection often begins at an ingrown toenail (see Ingrown Toenail).
Novel drug therapies, such as with inhibitors of epidermal growth factor receptor (EGFR), mammalian target of rapamycin (mTOR), and less commonly BRAF gene inhibitors, can cause paronychia along with other skin changes. The cause is not completely understood. However, most cases seem to be caused by the drug itself, such as through alterations in retinoic acid metabolism, and not by secondary infection.
In patients with diabetes and those with peripheral vascular disease, toe paronychia can threaten the limb.
Paronychia develops along the nail margin (lateral and/or proximal nail fold), manifesting over hours to days with pain, warmth, redness, and swelling. Pus usually develops along the nail margin and sometimes beneath the nail. Infection can spread to the fingertip pulp, causing a felon. Rarely, infection penetrates deep into the finger, sometimes causing infectious flexor tenosynovitis.
Diagnosis is by inspection. Several skin conditions can cause changes that mimic paronychia and should be considered, particularly when treatment is not effective initially. These conditions include squamous cell carcinoma, proximal onychomycosis, pyogenic granuloma, pyoderma gangrenosum, and herpetic whitlow.
Early treatment is warm compresses or soaks and an antistaphylococcal antibiotic (eg, dicloxacillin or cephalexin 250 mg po qid, clindamycin 300 mg po qid). In areas where methicillin-resistant S. aureus is common, antibiotics that are effective against this organism (eg, trimethoprim/sulfamethoxazole) should be chosen based on results of local sensitivity testing. In patients with diabetes and others with peripheral vascular disease, toe paronychia should be monitored for signs of cellulitis or more severe infection (eg, extension of edema or erythema, lymphadenopathy, fever).
Fluctuant swelling or visible pus should be drained with a Freer elevator, small hemostat, or #11 scalpel blade inserted between the nail and nail fold. Skin incision is unnecessary. A thin gauze wick can be inserted for 24 to 48 h to allow drainage.
A case caused by EGFR inhibitor therapy and refractory to the usual treatments was treated successfully with autologous platelet-rich plasma.
Acute paronychia can be related to a hangnail, nail fold trauma, loss of the cuticle, chronic irritation, or biting or sucking of the fingers.
The diagnosis is likely when severe redness, pain, and warmth develop acutely along the nail margin, but consider alternative diagnoses, particularly if treatment is unsuccessful.
Treat by draining any visible pus or, if none is visible, with an antibiotic and moist heat.
Drug NameSelect Trade
trimethoprimNo US brand name
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