* This is the Professional Version. *
Neurogenic bladder is bladder dysfunction (flaccid or spastic) caused by neurologic damage. Symptoms can include overflow incontinence, frequency, urgency, urge incontinence, and retention. Risk of serious complications (eg, recurrent infection, vesicoureteral reflux, autonomic dysreflexia) is high. Diagnosis involves imaging and cystoscopy or urodynamic testing. Treatment involves catheterization or measures to trigger urination.
Any condition that impairs bladder and bladder outlet afferent and efferent signaling can cause neurogenic bladder. Causes may involve the CNS (eg, stroke, spinal injury, meningomyelocele, amyotrophic lateral sclerosis), peripheral nerves (eg, diabetic, alcoholic, or vitamin B12 deficiency neuropathies; herniated disks; damage due to pelvic surgery), or both (eg, Parkinson disease, multiple sclerosis, syphilis). Bladder outlet obstruction often coexists and may exacerbate symptoms.
In flaccid (hypotonic) neurogenic bladder, volume is large, pressure is low, and contractions are absent. It may result from peripheral nerve damage or spinal cord damage at the S2 to S4 level. After acute cord damage, initial flaccidity may be followed by long-term flaccidity or spasticity, or bladder function may improve after days, weeks, or months.
In spastic bladder, volume is typically normal or small, and involuntary contractions occur. It usually results from brain damage or spinal cord damage above T12. Precise symptoms vary by site and severity of the lesion. Bladder contraction and external urinary sphincter relaxation are typically uncoordinated (detrusor-sphincter dyssynergia).
Mixed patterns (flaccid and spastic bladder) may be caused by many disorders, including syphilis, diabetes mellitus, brain or spinal cord tumors, stroke, ruptured intervertebral disk, and demyelinating or degenerative disorders (eg, multiple sclerosis, amyotrophic lateral sclerosis).
Overflow incontinence is the primary symptom in patients with a flaccid bladder. Patients retain urine and have constant overflow dribbling. Men typically also have erectile dysfunction.
Patients with spastic bladder may have frequency, nocturia, and spastic paralysis with sensory deficits; most have intermittent bladder contractions causing urine leakage and, unless they lack sensation, urgency. In patients with detrusor-sphincter dyssynergia, sphincter spasm during voiding may prevent complete bladder emptying.
Common complications include recurrent UTIs and urinary calculi. Hydronephrosis with vesicoureteral reflux may occur because the large urine volume puts pressure on the vesicoureteral junction, causing dysfunction with reflux and, in severe cases, nephropathy. Patients with high thoracic or cervical spinal cord lesions are at risk of autonomic dysreflexia (a life-threatening syndrome of malignant hypertension, bradycardia or tachycardia, headache, piloerection, and sweating due to unregulated sympathetic hyperactivity). This disorder may be triggered by acute bladder distention (due to urinary retention) or bowel distention (due to constipation or fecal impaction).
Diagnosis is suspected clinically. Usually, postvoid residual volume is measured, renal ultrasonography is done to detect hydronephrosis, and serum creatinine is measured to assess renal function.
Further studies are often not done in patients who are not able to self-catheterize or ask to go to the bathroom (eg, severely debilitated elderly or post-stroke patients).
In patients with hydronephrosis or nephropathy who are not severely debilitated, cystography, cystoscopy, and cystometrography with urodynamic testing are usually recommended and may guide further therapy. Cystography is used to evaluate bladder capacity and detect reflux. Cystoscopy is used to evaluate duration and severity of retention (by detecting bladder trabeculations) and to check for bladder outlet obstruction. Cystometrography can determine whether bladder volume and pressure are high or low; if done during the recovery phase of flaccid bladder after spinal cord injury, it can help evaluate detrusor functional capacity and predict rehabilitation prospects (see page Testing). Urodynamic testing of voiding flow rates with sphincter electromyography can show whether bladder contraction and sphincter relaxation are coordinated (see page Testing).
Prognosis is good if the disorder is diagnosed and treated before kidneys are damaged.
Specific treatment involves catheterization or measures to trigger urination. General treatment includes renal function monitoring, control of UTIs, high fluid intake to decrease risk of UTIs and urinary calculi (although this measure may exacerbate incontinence), early ambulation, frequent changes of position, and dietary Ca restriction to inhibit calculus formation.
For flaccid bladder, especially if the cause is an acute spinal cord injury, immediate continuous or intermittent catheterization is needed. Intermittent self-catheterization is preferable to indwelling urethral catheterization, which has a high risk of recurrent UTIs and, in men, a high risk of urethritis, periurethritis, prostatic abscesses, and urethral fistulas. Suprapubic catheterization may be used if patients cannot self-catheterize.
For spastic bladder, treatment depends on the patient’s ability to retain urine. Patients who can retain normal volumes can use techniques to trigger voiding (eg, applying suprapubic pressure, scratching the thighs); anticholinergics may be effective. For patients who cannot retain normal volumes, treatment is the same as that of urge incontinence (see page Urinary Incontinence in Adults : Treatment), including drugs (see Table: Drugs Used to Treat Incontinence) and sacral nerve stimulation.
Surgery is a last resort. It is usually indicated if patients have had or are at risk of severe acute or chronic sequelae or if social circumstances, spasticity, or quadriplegia prevents use of continuous or intermittent bladder drainage. Sphincterotomy (for men) converts the bladder into an open draining conduit. Sacral (S3 and S4) rhizotomy converts a spastic into a flaccid bladder. Urinary diversion may involve an ileal conduit or ureterostomy.
An artificial, mechanically controlled urinary sphincter, surgically inserted, is an option for patients who have adequate bladder capacity, good bladder emptying, and upper extremity motor skills and who can comply with instructions for use of the device; if patients do not comply, life-threatening situations (eg, renal failure, urosepsis) can result.
Damage to the neural pathways that control voiding can render the bladder too flaccid or spastic.
Flaccid bladder tends to cause overflow incompetence.
Spastic bladder tends to cause frequency, urge incontinence and, particularly with detrusor-sphincter dyssynergia, retention.
Measure postvoid residual volume, do renal ultrasonography and serum creatinine measurement, and in many patients, do cystography, cystoscopy, and cystometrography with urodynamic testing.
Treatment for flaccid bladder includes increased fluid intake and intermittent self-catheterization.
Treatment for spastic bladder may include or measures to trigger urination and/or measures used to treat urge incontinence (including drugs).
* This is the Professional Version. *