Not Found

Find information on medical topics, symptoms, drugs, procedures, news and more, written for the health care professional.

* This is the Professional Version. *


By Hans P. Schlecht, MD, MSc, Assistant Professor of Medicine, Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine ; Christopher Bruno, MD, Assistant Professor of Medicine, Division of infectious Diseases & HIV Medicine, Drexel University College of Medicine

Click here for
Patient Education

Monobactams are parenteral β-lactam bactericidal antibiotics.

Aztreonam is currently the only available monobactam. Aztreonam is as active as ceftazidime against

  • Enterobacteriaceae that do not produce ampC β-lactamase or extended-spectrum β-lactamase (ESBL)

  • Pseudomonas aeruginosa

Aztreonam is not active against anaerobes. Gram-positive bacteria are resistant to aztreonam (in contrast to cephalosporins). Aztreonam acts synergistically with aminoglycosides.

Because the metabolic products of aztreonam differ from those of other β-lactams, cross-hypersensitivity is unlikely. Thus, aztreonam is used mainly for

  • Severe aerobic gram-negative bacillary infections, including meningitis, in patients who have a serious β-lactam allergy but who nevertheless require β-lactam therapy

Other antibiotics are added to cover any suspected gram-positive cocci and anaerobes.

The dose is reduced in renal failure.

Drugs Mentioned In This Article

  • Drug Name
    Select Trade

* This is the Professional Version. *