Sections
Index
Symptoms
Cardiovascular Disorders
Clinical Pharmacology
Critical Care Medicine
Dental Disorders
Dermatologic Disorders
Ear, Nose, and Throat Disorders
Endocrine and Metabolic Disorders
Eye Disorders
Gastrointestinal Disorders
Genitourinary Disorders
Geriatrics
Gynecology and Obstetrics
Hematology and Oncology
Hepatic and Biliary Disorders
Immunology; Allergic Disorders
Infectious Diseases
Injuries; Poisoning
Musculoskeletal and Connective Tissue Disorders
Neurologic Disorders
Nutritional Disorders
Pediatrics
Psychiatric Disorders
Pulmonary Disorders
Special Subjects
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Abdominal Pain, Acute
Abdominal pain, Chronic
Alopecia
Amenorrhea
Amnesia
Anosmia
Bleeding, Excessive
Breast Lumps
Chest Pain
Constipation in Adults
Constipation in Children
Cough in Adults
Cough in Children
Crying
Diarrhea in Adults
Diarrhea in Children
Diplopia
Dizziness
Dry Mouth
Dysmenorrhea
Dyspepsia
Dysphagia
Dyspnea
Dysuria
Earache
Ear Discharge
Edema
Edema During Late Pregnancy
Epistaxis
Erectile dysfunction
Eyelid Swelling
Eye Pain
Fever
Fever, Acute, in Adults
Fever, Chronic (FUO)
Fever in Infants and Children
Floaters
Gas
Gastrointestinal Bleeding
Halitosis
Headache
Hearing Loss
Hearing Loss: Sudden Deafness
Hematospermia
Hematuria
Hemoptysis
Hiccups
Hirsutism
Insomnia and Excessive Daytime Sleepiness
Itching
Itching, Anal
Jaundice in Adults
Jaundice in Neonates
Joint Pain, Monarticular
Joint Pain, Polyarticular
Knee pain
Lump in Throat
Nasal Congestion and Rhinorrhea
Nausea and Vomiting During Early pPregnancy
Nausea and Vomiting in Adults
Nausea and Vomiting in Infants and Children
Neck and Back Pain
Neck Mass
Nipple Discharge
Orthostatis Hypotension
Pain
Pain, Chronic
Palpitations
Pelvic Pain
Pelvic Pain During Early Pregnancy
Polyuria
Priapism
Red Eye
Scrotal Pain
Sore Throat
Stomatitis
Stridor
Syncope
Tearing
Tinnitus
Toothache
Tremor
Urinary Frequency
Urinary Incontinence in Adults
Urinary Incontinence in Children
Urinary Retention
Urticaria
Vaginal Bleeding
Vaginal Bleeding During Early Pregnancy
Vaginal Bleeding During Late Pregnancy
Vaginal Itching and Discharge
Vision, Blurred
Vision Loss, Acute
Weakness, Generalized
Wheezing
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Health Care Professionals
Cardiovascular Disorders
Clinical Pharmacology
Critical Care Medicine
Dental Disorders
Dermatologic Disorders
Ear, Nose, and Throat Disorders
Endocrine and Metabolic Disorders
Eye Disorders
Gastrointestinal Disorders
Genitourinary Disorders
Geriatrics
Gynecology and Obstetrics
Hematology and Oncology
Hepatic and Biliary Disorders
Immunology; Allergic Disorders
Infectious Diseases
Injuries; Poisoning
Musculoskeletal and Connective Tissue Disorders
Neurologic Disorders
Nutritional Disorders
Pediatrics
Psychiatric Disorders
Pulmonary Disorders
Special Subjects
Merck Manual
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Health Care Professionals
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Special Subjects
Special Subjects
General Principles of Medical Genetics
Overview of Genetics
Structure
Gene Function
Traits and Inheritance Patterns
Construction of a family pedigree
Single-Gene Defects
Autosomal Dominant
Autosomal Recessive
X-Linked Dominant
X-Linked Recessive
Factors Affecting Gene Expression
Penetrance and expressivity
Sex-limited inheritance
Genomic imprinting
Codominance
Chromosomal inactivation
Multifactorial (Complex) Inheritance
Unusual Aspects of Inheritance
Mutations and polymorphisms
Mosaicism
Extra or missing chromosomes
Uniparental disomy
Chromosomal translocation
Triplet (trinucleotide) repeat disorders
Anticipation
Mitochondrial DNA Abnormalities
Genetic Diagnostic Technologies
Clinical Uses of Genetics
Disease Understanding
Diagnosis
Genetic Screening
Treatment
Pharmacogenomics
Gene therapy
Ethical Controversies in Genetics
Clinical Decision Making
Introduction
Evidence-Based Medicine and Clinical Guidelines
Evidence-Based Medicine
Formulating a clinical question
Gathering evidence to answer the question
Evaluating the quality and validity of the evidence
Deciding how to apply the evidence to the care of a given patient
Limitations
Clinical Guidelines
Clinical Decision-Making Strategies
Hypothesis generation
Hypothesis testing
Probability Estimations and the Treatment Threshold
Limitations
Cognitive Errors in Clinical Decision Making
Types of cognitive error
Minimizing cognitive errors
Testing
Defining a Positive Test Result
Receiver operating characteristic (ROC) curves
Test Characteristics
Sensitivity, specificity, and predictive values
Likelihood ratios (LRs)
Dichotomous Tests
Continuous Tests
Bayes' Theorem
Odds-likelihood calculation
Odds-likelihood nomogram
Tabular approach
Sequential Testing
Screening Tests
Multiple screening tests
Testing Thresholds
Economic Analyses in Clinical Decision Making
Cost
Marginal cost
Outcome
Cost-Benefit Analysis
Marginal cost-effectiveness ratio
Principles of Radiologic Imaging
Radiation and Imaging
Risks of Ionizing Radiation
Radiation during pregnancy
Recommendations
Radiographic Contrast Agents and Contrast Reactions
Allergic-type contrast reactions
Contrast nephropathy
Angiography
Uses
Variations
Digital subtraction angiography
Disadvantages
Computed Tomography
Uses
Variations
Virtual colonoscopy
CT IV pyelography (CT IVP) or urography
CT angiography
Disadvantages
Magnetic Resonance Imaging
Uses
Contrast
Variations
Diffusion (diffusion-weighted) MRI
Echo planar imaging
Functional MRI
Gradient echo imaging
Magnetic resonance spectroscopy (MRS)
Perfusion MRI
Disadvantages
Magnetic field
Claustrophobia
Contrast reactions
Radiography
Variations
Contrast studies
Fluoroscopy
Disadvantages
Radionuclide Scanning
Uses
Variations
Single-photon emission CT (SPECT)
Disadvantages
Positron Emission Tomography
Uses
Variations
PET-CT
Disadvantages
Ultrasonography
Variations
A-mode
B-mode (gray-scale)
M-mode
Doppler
Disadvantages
Complementary and Alternative Medicine
Overview of Complementary and Alternative Medicine
Efficacy
Research
Safety
Categories
Alternative Whole Medical Systems
Ayurveda
Evidence
Uses
Possible adverse effects
Homeopathy
Evidence
Uses
Possible adverse effects
Naturopathy
Traditional Chinese Medicine
Evidence
Possible adverse effects
Mind-Body Medicine
Biofeedback
Uses
Guided imagery
Uses
Hypnotherapy
Uses
Meditation
Uses
Relaxation Techniques
Biologically Based Practices
Diet Therapy
Orthomolecular Medicine
Evidence and uses
Possible adverse effects
Chelation Therapy
Manipulative and Body-Based Practices
Chiropractic
Uses
Possible adverse effects
Massage Therapy
Reflexology
Structural integration
Other Therapies
Cupping
Scraping
Moxibustion
Energy Medicine
Acupuncture
Evidence and uses
Possible adverse effects and contraindications
Magnets
Evidence and uses
Possible contraindications
Therapeutic Touch
Reiki
Dietary Supplements
Overview of Dietary Supplements
Definition
Labeling
Safety and efficacy
Purity and standardization
Other concerns
Black Cohosh
Claims
Adverse effects
Chamomile
Claims
Adverse effects
Chondroitin Sulfate
Claims
Adverse effects
Chromium
Claims
Adverse effects
Coenzyme Q10
Claims
Adverse effects
Cranberry
Claims
Adverse effects
Creatine
Claims
Adverse effects
Dehydroepiandrosterone (DHEA)
Claims
Adverse effects
Echinacea
Claims
Adverse effects
Feverfew
Claims
Adverse effects
Fish Oil
Claims
Adverse effects
Garlic
Claims
Adverse effects
Ginger
Claims
Adverse effects
Ginkgo
Claims
Adverse effects
Ginseng
Claims
Adverse effects
Glucosamine
Claims
Adverse effects
Goldenseal
Claims
Adverse effects
Green Tea
Claims
Adverse effects
Kava
Claims
Adverse effects
Licorice
Claims
Adverse effects
Melatonin
Claims
Adverse effects
Milk Thistle
Claims
Adverse effects
S
-Adenosyl-
l
-Methionine
Claims
Adverse effects
Saw Palmetto
Claims
Adverse effects
St. John's Wort
Claims
Adverse effects
Valerian
Claims
Adverse effects
Zinc
Claims
Adverse effects
Drug Use and Dependence
Overview of Drug Use and Dependence
Definitions
Narcotics and scheduled drugs
Drug Dependence
Drug
User
Setting
Injection Drug Use
Complications
Adulterants
Infectious agents
Diagnosis
Treatment
Drug Testing
False results
Body Packing
Diagnosis
Treatment
Opioids
Pathophysiology
Chronic effects
Pregnancy
Symptoms and Signs
Acute effects
Toxicity or overdose
Withdrawal
Diagnosis
Treatment
Toxicity or overdose
Withdrawal and detoxification
Opioid Abuse and Rehabilitation
Treatment
Maintenance
Support
Alcohol
Pathophysiology
Chronic effects
Special populations
Symptoms and Signs
Acute effects
Toxicity or overdose
Chronic effects
Withdrawal
Diagnosis
Treatment
Toxicity or overdose
Withdrawal
Alcohol Problems and Rehabilitation
Definitions
Etiology
Symptoms and Signs
Diagnosis
Treatment
Maintenance
Wernicke's Encephalopathy
Symptoms and Signs
Diagnosis
Prognosis
Treatment
Korsakoff's Psychosis
Symptoms and Signs
Diagnosis
Prognosis
Treament
Marchiafava-Bignami Disease
Anxiolytics and Sedatives
Pathophysiology
Chronic effects
Pregnancy
Symptoms and Signs
Toxicity or overdose
Withdrawal
Diagnosis
Treatment
Toxicity or overdose
Withdrawal and detoxification
Marijuana (Cannabis)
Pathophysiology
Chronic effects
Symptoms and Signs
Acute effects
Withdrawal
Diagnosis
Treatment
Cocaine
Pathophysiology
Pregnancy
Symptoms and Signs
Acute effects
Toxicity or overdose
Chronic effects
Withdrawal
Diagnosis
Treatment
Toxicity or overdose
Abuse
Amphetamines
Pathophysiology
Chronic effects
Symptoms and Signs
Acute effects
Toxicity or overdose
Chronic effects
Withdrawal
Diagnosis
Treatment
Toxicity or overdose
Withdrawal and rehabilitation
Methylenedioxymethamphetamine (Ecstasy, MDMA)
Symptoms and Signs
Diagnosis
Treatment
Hallucinogens
Pathophysiology
Symptoms and Signs
Diagnosis
Treatment
Ketamine and Phencyclidine (PCP)
Symptoms and Signs
Diagnosis
Treatment
Volatile Nitrites
Volatile Solvents
Symptoms and Signs
Diagnosis
Treatment
Gamma Hydroxybutyrate
Anabolic Steroids
Pathophysiology
Chronic effects
Symptoms and Signs
Diagnosis
Treatment
Prevention
Substance Use in Children and Adolescents
Diagnosis
Smoking Cessation
Smoking Cessation
Epidemiology
Smoking
Complications
Quitting
Passive smoking
Symptoms and Signs
Treatment
Identifying smokers
Evidence-based counseling
Drugs
Drug safety
Cessation in children
Prognosis
Other Kinds of Tobacco
Cessation
Medical Aspects of Travel
Introduction
Air Travel
Barometric pressure changes
Children
Circadian dysrhythmia (jet lag)
Decreased O
2
tension
Low cabin humidity
Motion sickness
Pregnancy
Psychologic stress
Restricted mobility
Turbulence
Other issues
Foreign Travel
Vaccinations
Injury and death
Traveler's diarrhea
Schistosomiasis
Problems after returning home
Syndromes of Uncertain Origin
Introduction
Chronic Fatigue Syndrome
Etiology
Symptoms and Signs
Diagnosis
Treatment
Multiple Chemical Sensitivity Syndrome
Etiology
Triggers
Mechanism
Symptoms and Signs
Diagnosis
Treatment
Gulf War Syndrome
Care of the Surgical Patient
Introduction
Preoperative Evaluation
History
Physical examination
Testing
Surgical risk factors
Perioperative Management
Diabetes
Corticosteroids
Anticoagulants and antiplatelets
Other drugs that control chronic disorders
Drug dependence
Smoking
Upper airway
Preprocedural checklist
Outpatient Procedures
Preparation
Discharge precautions
Antibiotic Prophylaxis for Surgical Procedures
Postoperative Care
Airway
Pain
Mental status
Wound care
Deep venous thrombosis (DVT) prophylaxis
Fever
Other issues
Rehabilitation
Overview of Rehabilitation
Referral
Goals of therapy
Patient and caregiver issues
Geriatric Rehabilitation
Physical Therapy (PT)
Range of motion
Strength and conditioning
Proprioceptive neuromuscular facilitation
Coordination exercises
Ambulation exercises
Transfer training
Occupational Therapy (OT)
Evaluation
Interventions
Speech Therapy
Therapeutic and Assistive Devices
Rehabilitative Measures for Treatment of Pain and Inflammation
Heat
Cold
Electrical stimulation
Cervical traction
Massage
Acupuncture
Cardiovascular Rehabilitation
Stroke Rehabilitation
Hemiplegia
Ambulation problems
Spasticity
Hemianopia
Occupational therapy
Leg Amputation Rehabilitation
Stump Conditioning and Prostheses
Care of the stump and prosthesis
Complications
Hip Surgery Rehabilitation
Rehabilitation For Other Disorders
Arthritis
Blindness
COPD
Head injury
Spinal cord injury
Exercise
Overview of Exercise
Stretching and flexibility
Aerobic exercise
Strength training
Balance training
Hydration
Exercise in the Elderly
Contraindications
Screening
Exercise program
The Dying Patient
The Dying Patient
When Death Is Near
After Death Occurs
Hospice Care
Other Concerns Related to Dying
Managing disability
Financial concerns
Legal and ethical concerns
Symptom Control in the Dying
Pain
Dyspnea
Anorexia
Nausea and Vomiting
Constipation
Pressure Ulcers
Confusion
Depression
Stress
Grief
Medicolegal Issues
Capacity (Competence) and Incapacity
Clinical capacity
Legal capacity
Informed Consent
Consent and Surrogate Decision Making
Children
Adults
Scope
Confidentiality and HIPAA
Access to medical records
Notice of privacy practices
Limits on use of personal medical information
Marketing
Confidential communications
Complaints
Advance Directives
Living will
Durable power of attorney for health care
Do-Not-Resuscitate (DNR) Orders and Physician Orders for Life-Sustaining Treatment (POLST)
Medical Malpractice
Financial Issues in Health Care
Overview of Health Care Financing
Funding
Private insurance
Government insurance programs
Out of pocket
Causes of High Health Care Costs
Use of costly new technologies and drugs
Increased costs of health care goods and services
Marketing of new drugs and devices
Overuse of specialty care
High administrative costs
Physician fees
Malpractice costs
Defensive medicine
Aging of the population
Containing Health Care Costs
Decreasing Use of Health Care Services
Limiting access to health care
Eliminating unnecessary care
Improving health
Decreasing Reimbursement for Care Used
Lower fees
Increased use of primary care
Prospective payment systems
Denial of claims
Competition
Decreased drug costs
Negative effects on medical research
Decreasing Overhead
Decreasing payor overhead
Decreasing provider overhead
Limb Prosthetics
Limb Prosthetics
Prosthetic Parts and Options
Interface
Components
Cover
Options
Preparing to Use a Prosthesis
Fitting the Prosthesis
Skin Care of the Stump
Preventing skin breakdown
Skin infections
Preventing other skin problems
Stump Swelling
Loosening of the Prosthesis
Stump Pain
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Figures
Photographs
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Tables
Videos
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