Components of Blood

Plasma is the liquid component of blood, in which the red blood cells, white blood cells, and platelets are suspended. It constitutes more than half of the blood's volume and consists mostly of water that contains dissolved salts (electrolytes) and proteins. The major protein in plasma is albumin. Albumin helps keep fluid from leaking out of blood vessels and into tissues, and albumin binds to and carries substances such as hormones and certain drugs. Other proteins in plasma include antibodies Antibodies One of the body's lines of defense ( immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more (immunoglobulins), which actively defend the body against viruses, bacteria, fungi, and cancer cells, and clotting factors How Blood Clots Hemostasis is the body's way of stopping injured blood vessels from bleeding. Hemostasis includes clotting of the blood. Too little clotting can cause excessive bleeding from minor injury Too... read more , which control bleeding.

Plasma has other functions. It acts as a reservoir that can either replenish insufficient water or absorb excess water from tissues. When body tissues need additional liquid, water from plasma is the first resource to meet that need. Plasma also prevents blood vessels from collapsing and clogging and helps maintain blood pressure and circulation throughout the body simply by filling blood vessels and flowing through them continuously. Plasma circulation also plays a role in regulating body temperature by carrying heat generated in core body tissues through areas that lose heat more readily, such as the arms, legs, and head.

Red blood cells (also called erythrocytes) make up about 40% of the blood's volume. Red blood cells contain hemoglobin, a protein that gives blood its red color and enables it to carry oxygen from the lungs and deliver it to all body tissues. Oxygen is used by cells to produce energy that the body needs, leaving carbon dioxide as a waste product. Red blood cells carry carbon dioxide away from the tissues and back to the lungs. When the number of red blood cells is too low (anemia Overview of Anemia Anemia is a condition in which the number of red blood cells is low. Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts... read more ), blood carries less oxygen, and fatigue and weakness develop. When the number of red blood cells is too high (erythrocytosis, as in polycythemia vera Polycythemia Vera Polycythemia vera is a myeloproliferative neoplasm of the blood-producing cells of the bone marrow that results in overproduction of all types of blood cells. Polycythemia vera is due to mutations... read more ), blood can become too thick, which may cause the blood to clot more easily and increase the risk of heart attacks Acute Coronary Syndromes (Heart Attack; Myocardial Infarction; Unstable Angina) Acute coronary syndromes result from a sudden blockage in a coronary artery. This blockage causes unstable angina or a heart attack (myocardial infarction), depending on the location and amount... read more and strokes Overview of Stroke A stroke occurs when an artery to the brain becomes blocked or ruptures, resulting in death of an area of brain tissue due to loss of its blood supply (cerebral infarction) and symptoms that... read more .

White blood cells (also called leukocytes) are fewer in number than red blood cells, with a ratio of about 1 white blood cell to every 600 to 700 red blood cells Red Blood Cells The main components of blood include Plasma Red blood cells White blood cells Platelets read more . White blood cells are responsible primarily for defending the body against infection. There are five main types of white blood cells.

Neutrophils Neutrophils One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more , the most numerous type, help protect the body against infections by killing and ingesting bacteria and fungi and by ingesting foreign debris.

Lymphocytes Lymphocytes One of the body's lines of defense ( immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more consist of three main types: T cells T cells One of the body's lines of defense ( immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more (T lymphocytes) and natural killer cells Natural Killer Cells One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more , which both help protect against viral infections and can detect and destroy some cancer cells, and B cells B cells One of the body's lines of defense ( immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more (B lymphocytes), which develop into cells that produce antibodies.

Monocytes Monocytes and Macrophages One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more ingest dead or damaged cells and help defend against many infectious organisms.

Eosinophils Eosinophils One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more kill parasites, destroy cancer cells, and are involved in allergic responses.

Basophils Basophils One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more also participate in allergic responses.

Some white blood cells flow smoothly through the bloodstream, but many adhere to blood vessel walls or even penetrate the vessel walls to enter other tissues. When white blood cells reach the site of an infection or other problem, they release substances that attract more white blood cells. The white blood cells function like an army, dispersed throughout the body but ready at a moment's notice to gather and fight off an invading organism. White blood cells White blood cells accomplish this by engulfing and digesting organisms and by producing antibodies that attach to organisms so that they can be more easily destroyed.

When the number of white blood cells is too low (leukopenia White Blood Cells ), infections are more likely to occur. A higher than normal number of white blood cells (leukocytosis Overview of White Blood Cell Disorders ) may not directly cause symptoms, but the high number of cells can be an indication of an underlying disorder such as an infection, inflammatory process, or leukemia Overview of Leukemia Leukemias are cancers of white blood cells or of cells that develop into white blood cells. White blood cells develop from stem cells in the bone marrow. Sometimes the development goes awry... read more .

Platelets (also called thrombocytes) are cell-like particles that are smaller than red or white blood cells. Platelets are fewer in number than red blood cells, with a ratio of about 1 platelet to every 20 red blood cells. Platelets help in the clotting process by gathering at a bleeding site and clumping together to form a plug that helps seal the blood vessel. At the same time, they release substances that help promote further clotting. When the number of platelets is too low (thrombocytopenia Overview of Thrombocytopenia Thrombocytopenia is a low number of platelets (thrombocytes) in the blood, which increases the risk of bleeding. Thrombocytopenia occurs when the bone marrow makes too few platelets or when... read more ), bruising and abnormal bleeding become more likely. When the number of platelets is too high (thrombocythemia Essential Thrombocythemia Essential thrombocythemia is a myeloproliferative neoplasm in which excess platelets are produced, leading to abnormal blood clotting or bleeding. The hands and feet may burn, turn red, and... read more ), blood may clot excessively and can block blood vessels causing disorders such as a transient ischemic attack Transient Ischemic Attacks (TIAs) A transient ischemic attack (TIA) is a disturbance in brain function that typically lasts less than 1 hour and results from a temporary blockage of the brain’s blood supply. The cause and symptoms... read more . When the number of platelets is extremely high, the platelets can absorb clotting proteins and paradoxically cause bleeding.