Merck Manual

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Overview of Hereditary Periodic Fever Syndromes

By

Apostolos Kontzias

, MD, Stony Brook University School of Medicine

Last full review/revision Sep 2021
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Topic Resources

Hereditary periodic fever syndromes are hereditary disorders that periodically cause episodes of fever and other symptoms that are not due to usual childhood infections or any other obvious disorder.

The most common hereditary periodic fever syndrome across all age groups is

A similar disorder that causes episodes of fever but is not thought to be hereditary is

Other less common syndromes include the following:

Symptoms of hereditary periodic fever syndromes usually begin during childhood. Fewer than 10% of people develop symptoms after age 18. People periodically have attacks of fever and inflammation but feel well between attacks.

Drugs Mentioned In This Article

Generic Name Select Brand Names
KINERET
ARCALYST
ILARIS
RAYOS
ENBREL
ACHROMYCIN V
ABSORICA
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