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Bronchiolitis

By

Rajeev Bhatia

, MD, Phoenix Children's Hospital

Last full review/revision Jul 2020| Content last modified Jul 2020
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Bronchiolitis is a viral infection that affects the lower respiratory tract of infants and young children under 24 months of age.

  • Bronchiolitis usually is caused by viruses.

  • Symptoms include runny nose, fever, cough, wheezing, and difficulty breathing.

  • The diagnosis is based on symptoms and a physical examination.

  • Most children do well at home and recover in a few days, but some need to be hospitalized.

  • Treatment is primarily supporting the child through the illness with fluids and occasionally with oxygen.

The airways resemble an upside-down tree. The trunk is the windpipe (trachea), which branches into large airways called bronchi. The bronchi themselves branch many times into smaller airways, ending in the smallest airways, which are called bronchioles. Bronchioles are as small as one half of a millimeter (or 2/100 of an inch) across. Their walls have a thin, circular layer of smooth muscle that can relax or contract, thus changing airway size.

Bronchiolitis typically affects children younger than 24 months of age and is most common among infants younger than 6 months of age. During the first year of life, bronchiolitis affects about 11 of every 100 children. However, during some epidemics, a much higher proportion of infants are affected. Most cases occur between November and April, with a peak incidence during January and February.

Causes

Bronchiolitis is most often caused by

Infection with any of these viruses can cause inflammation of the airways. The inflammation causes the airways to narrow, obstructing the flow of air into and out of the lungs. In severe cases, children have a low level of oxygen in their bloodstream.

The infection may be more common or more severe among infants whose mothers smoke cigarettes, particularly those who smoked during pregnancy. The infection seems to be less common among breastfed infants. Parents and older siblings can be infected with the same virus, but for them the virus usually causes only a mild cold.

Symptoms

Bronchiolitis starts with symptoms of a cold—runny nose, sneezing, mild fever, and some coughing. After several days, children develop difficulty breathing, with rapid breathing and a worsening cough. Usually children make a high-pitched sound when breathing out (wheezing). In most infants, the symptoms are mild. Even though infants may breathe somewhat rapidly and be very congested, they are alert, happy, and eating well.

More severely affected infants breathe rapidly and shallowly, use a lot of their respiratory muscles to breathe, and have flaring of their nostrils. They seem fussy and anxious and can become dehydrated because of vomiting and difficulty with drinking. A fever usually is present but not always. Some children also develop an ear infection. Premature infants or infants younger than 2 months sometimes have episodes where they stop breathing briefly (apnea). In very severe and unusual cases, the child may become blue around the mouth because of a lack of oxygen.

Diagnosis

  • A doctor's evaluation

  • Pulse oximetry

  • Sometimes mucus swab or chest x-ray

A doctor bases the diagnosis of bronchiolitis on the symptoms and the physical examination. Doctors measure oxygen levels in the blood by placing a sensor on a finger (pulse oximetry).

For severe cases, doctors sometimes swab mucus from deep inside the nose to try to identify the virus in the laboratory or do a chest x-ray. Other laboratory tests may be done.

Prognosis

Most children recover at home in 3 to 5 days. However, wheezing and coughing may continue for 2 to 4 weeks. With proper care, the chance of developing serious consequences due to bronchiolitis is low, even for children who need to be hospitalized.

Some children have repeated episodes of wheezing after having had bronchiolitis.

Treatment

  • At home, fluids by mouth

  • In the hospital, oxygen therapy and fluids by vein

Home treatment

Most children can be treated at home with fluids and comfort measures.

During the illness, frequent small feedings of clear fluids may be given. Increasing difficulty in breathing, bluish skin discoloration, fatigue, and dehydration indicate that the child should be hospitalized. Children who have congenital heart disease or lung disease or an impaired immune system may be hospitalized sooner and are far more likely to become quite ill from bronchiolitis.

Hospital treatment

In the hospital, oxygen levels are monitored with a sensor attached to a finger or toe, and oxygen is given by an oxygen tent, nasal tube (cannula), or face mask (see Oxygen administration). Rarely, a ventilator (a breathing machine that helps air get in and out of the lungs) may be needed to assist breathing.

Fluids are given by vein if the child cannot drink adequately.

Inhaled drugs that open the airways (bronchodilators) may be tried. Although these drugs relieve wheezing and airway narrowing caused by asthma, their effectiveness in treating bronchiolitis is questionable. Corticosteroids (to suppress inflammation) may be beneficial for some children.

Doctors no longer use the antiviral drug ribavirin (given by nebulizer) except for children whose immune system is extremely weak and whose infection is severe. Antibiotics are not helpful unless the child also has a bacterial infection.

Prevention

Children who are at high risk of serious complications, such as those who have severe congenital heart disease or who were born very prematurely, may be given palivizumab to help prevent respiratory syncytial virus (RSV) infection. Palivizumab is an antibody to RSV.

Drugs Mentioned In This Article

Generic Name Select Brand Names
VIRAZOLE
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