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ZAP-70 Deficiency

By

James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Last full review/revision Apr 2021| Content last modified Apr 2021
CLICK HERE FOR THE PROFESSONAL VERSION

ZAP-70 (zeta-associated protein 70) deficiency is a genetic disorder of the immune system that results in an abnormality in T cells that prevents T cells from becoming activated to fight specific infections.

ZAP-70 deficiency causes recurrent infections similar to those in severe combined immunodeficiency Severe Combined Immunodeficiency (SCID) Severe combined immunodeficiency is a primary immunodeficiency disorder resulting in low levels of antibodies (immunoglobulins) and low or no T cells (lymphocytes). Most infants with severe... read more (SCID) in infants and young children. However, the deficiency may not be diagnosed until children are several years old.

More Information about ZAP-70 Deficiency

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Gammagard S/D
No US brand name
DILANTIN
AZULFIDINE
BACTRIM, SEPTRA
SPORANOX
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Severe Combined Immunodeficiency (SCID)
Severe combined immunodeficiency (SCID) is a genetic disorder that causes low levels of antibodies and T-cells (a type of cell that attacks foreign substances). Individuals with severe SCID have virtually no protection from bacteria, fungi, or viruses. As a result, they are prone to repeated and persistent infections. Which of the following is the age at which SCID usually first presents?
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