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Central Diabetes Insipidus


The Manual's Editorial Staff

Medically Reviewed Feb 2021 | Modified Sep 2022
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What is central diabetes insipidus?

Central diabetes insipidus is not having enough of a hormone called vasopressin. Hormones are chemicals that stimulate other cells or tissues into action. Vasopressin is a hormone that signals your kidneys to make less urine (pee) so your body retains water. Vasopressin is made in part of your brain called the hypothalamus, and then it's stored and released from your pituitary gland Overview of the Pituitary Gland The pituitary gland is a pea-sized bit of tissue at the bottom of your brain. Glands are organs that make and release hormones into your blood. Hormones are chemicals that stimulate other cells... read more . The hypothalamus and pituitary are both located at the bottom of your brain.

  • Having low levels of vasopressin makes you urinate a lot so you get very thirsty

  • Central diabetes insipidus is usually caused by a brain problem, such as a tumor or injury, or brain surgery

  • Doctors do urine tests and blood tests after you've gone without drinking water for about 12 hours

  • Doctors usually treat central diabetes insipidus with vasopressin nasal spray

Central diabetes insipidus is different from the common disease called diabetes Diabetes Diabetes is a disease in which your blood sugar (glucose) levels are too high. You get diabetes if your body's normal way of controlling blood sugar isn't working right. There are 2 types of... read more , in which your blood sugar is too high. That blood sugar disease is diabetes mellitus. Other than making you pee a lot, diabetes insipidus has nothing to do with diabetes mellitus.

What causes central diabetes insipidus?

What are the symptoms of central diabetes insipidus?

Symptoms of central diabetes insipidus include:

  • Extreme thirst, especially for ice cold water—some people drink up to 10 gallons a day

  • Urinating very often (including waking up at night to urinate)

How can doctors tell if I have central diabetes insipidus?

Doctors test for central diabetes insipidus using:

  • Urine tests

  • Blood tests

Doctors do the blood and urine tests while you're not drinking any water. You may have to go without drinking for up to 12 hours (a water deprivation test). If you keep peeing despite not drinking anything, you may have central diabetes insipidus. Then doctors give you a shot of vasopressin and see how your body reacts.

How do doctors treat central diabetes insipidus?

Doctors treat central diabetes insipidus using one of the following:

  • Nasal spray with desmopressin (a long-acting form of vasopressin)

  • Medicine to help your body make vasopressin

Drugs Mentioned In This Article

Generic Name Select Brand Names
Pitressin, Vasostrict
DDAVP, Minirin, Nocdurna, Noctiva, Stimate
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