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Infectious Mononucleosis (Mono)


The Manual's Editorial Staff

Reviewed/Revised Feb 2024
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What is infectious mononucleosis?

  • Mono is spread by close contact, such as kissing, with infected people

  • Symptoms include a very sore throat, extreme tiredness, and swollen lymph nodes in your neck

  • People with mono usually feel better after about 2 weeks, but some people may feel very tired for weeks or even months

  • Acetaminophen or ibuprofen lowers fever and lessens pain

What causes mono?

Mono is caused by the Epstein-Barr virus, a type of herpesvirus Overview of Herpesvirus Infections Herpesviruses are a group of viruses that can cause several different infections. The disease most people call "herpes," called herpes simplex, is just one of the types of herpesvirus. Once... read more . Infection with Epstein-Barr virus (EBV) is common, but not everyone who gets it gets mono. Many people with EBV infection have no symptoms or very mild symptoms.

What are the symptoms of mono?

Symptoms of mono include:

You can have mono without having all of these symptoms.

About half of people with mono have a swollen spleen. Your spleen is an organ in the left side of your belly just below your ribcage. It's about the size of a fist. The spleen makes blood cells that help your immune system and also gets rid of blood cells that are old or abnormal. A spleen is more likely to burst if your belly is injured while your spleen is swollen.

If mono is very severe, it can cause low blood count and problems with your liver, heart, and nerves.

How can doctors tell if I have mono?

Doctors may suspect mono from your symptoms, especially if you have swollen lymph nodes in your neck. To know for sure, they'll do blood tests.

How do doctors treat mono?

There are no medicines to cure mono. Antiviral drugs don't help. Doctors will:

  • Tell you to rest for a week or two, when you’re feeling the most tired and weak

  • Have you take acetaminophen or ibuprofen to help your fever and pain

  • Have you take corticosteroids, if your tonsils are so swollen and painful that you're having trouble swallowing or breathing

After 2 weeks, as you start to feel better, you can be more active—just don’t lift anything heavy or play contact sports (like football) until your doctor tells you that your spleen is back to its normal size.

Drugs Mentioned In This Article

Generic Name Select Brand Names
7T Gummy ES, Acephen, Aceta, Actamin, Adult Pain Relief, Anacin Aspirin Free, Aphen, Apra, Children's Acetaminophen, Children's Pain & Fever , Children's Pain Relief, Comtrex Sore Throat Relief, ED-APAP, ElixSure Fever/Pain, Feverall, Genapap, Genebs, Goody's Back & Body Pain, Infantaire, Infants' Acetaminophen, LIQUID PAIN RELIEF, Little Fevers, Little Remedies Infant Fever + Pain Reliever, Mapap, Mapap Arthritis Pain, Mapap Infants, Mapap Junior, M-PAP, Nortemp, Ofirmev, Pain & Fever , Pain and Fever , PAIN RELIEF , PAIN RELIEF Extra Strength, Panadol, PediaCare Children's Fever Reducer/Pain Reliever, PediaCare Children's Smooth Metls Fever Reducer/Pain Reliever, PediaCare Infant's Fever Reducer/Pain Reliever, Pediaphen, PHARBETOL, Plus PHARMA, Q-Pap, Q-Pap Extra Strength, Silapap, Triaminic Fever Reducer and Pain Reliever, Triaminic Infant Fever Reducer and Pain Reliever, Tylenol, Tylenol 8 Hour, Tylenol 8 Hour Arthritis Pain, Tylenol 8 Hour Muscle Aches & Pain, Tylenol Arthritis Pain, Tylenol Children's, Tylenol Children's Pain+Fever, Tylenol CrushableTablet, Tylenol Extra Strength, Tylenol Infants', Tylenol Infants Pain + Fever, Tylenol Junior Strength, Tylenol Pain + Fever, Tylenol Regular Strength, Tylenol Sore Throat, XS No Aspirin, XS Pain Reliever
Advil, Advil Children's, Advil Children's Fever, Advil Infants', Advil Junior Strength, Advil Migraine, Caldolor, Children's Ibuprofen, ElixSure IB, Genpril , Ibren , IBU, Midol, Midol Cramps and Body Aches, Motrin, Motrin Children's, Motrin IB, Motrin Infants', Motrin Junior Strength, Motrin Migraine Pain, PediaCare Children's Pain Reliever/Fever Reducer IB, PediaCare Infants' Pain Reliever/Fever Reducer IB, Samson-8
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