Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

Melasma

(Chloasma)

By

Shinjita Das

, MD, Harvard Medical School

Last full review/revision Jan 2021| Content last modified Jan 2021
Click here for the Professional Version
Topic Resources

Melasma is dark brown patches of pigmentation that appear on sun-exposed areas of the skin, usually the face.

  • Patchy areas of dark color appear on the skin.

  • Doctors usually base the diagnosis on an examination of the skin.

  • Treatment includes sun protection and skin-bleaching creams.

People who spend a lot of time in the sun are at increased risk of melasma. Other risk factors include autoimmune thyroid disorders and drugs that make some people's skin more sensitive to the effects of sunlight.

Symptoms of Melasma

Irregular, patchy areas of dark color appear on the skin, usually on both sides of the face. The pigmentation most often occurs in the center of the face and on the cheeks, forehead, temples, upper lip, and nose. Sometimes people have the patches only on the sides of the face. Rarely, melasma appears on the forearms. The patches do not itch or hurt and are only of cosmetic concern.

Diagnosis of Melasma

  • A doctor's evaluation

  • Wood light examination

Doctors base the diagnosis of melasma on an examination of the skin.

Treatment of Melasma

  • Sun protection

  • Skin-bleaching creams

  • Sometimes chemical peels

Treatments applied to the skin are effective only if hyperpigmentation affects the upper layers of the skin. Skin-bleaching creams containing hydroquinone, tretinoin, or a corticosteroid can be used in combination to help lighten the dark patches. Hydroquinone should be used only under the guidance of a doctor, because long-term use can actually cause permanent hyperpigmentation. A cream containing azelaic acid can be used in place of or combined with hydroquinone, tretinoin, or both.

Doctors may try chemical peels with glycolic acid or trichloroacetic acid on people who do not respond to skin-bleaching creams.

Laser treatments and tranexamic acid, which is a drug taken by mouth, are also used.

During and after treatment, people must be strict about sun protection because treatments make the skin prone to sunburn. Also, even a few hours of sun exposure can cause hyperpigmentation to begin again in the treated areas, which would undo the results of months of treatment.

If the skin is protected from the sun, melasma often fades after pregnancy or after an oral contraceptive is stopped. In men, melasma rarely fades.

Drugs Mentioned In This Article

Generic Name Select Brand Names
CYKLOKAPRON
AZELEX, FINACEA
TRI-LUMA
NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
Click here for the Professional Version
Others also read

Test your knowledge

Psoriasis
Psoriasis is a common chronic disease affecting 1 to 5% of the population worldwide. It causes distinctive raised, red patches with silvery scales. A border between the patch and normal skin is known as “psoriatic plaque.”  Which of the following is the reason these patches of plaque form?
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest

Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
TOP